Effects of particulate matter exposure on multiple sclerosis hospital admission in Lombardy region, Italy.
Effects of particulate matter exposure on multiple sclerosis hospital admission in Lombardy region, Italy.
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DOI：
10.1016/j.envres.2015.11.017
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发表时间：
2016-02
影响因子：
8.3
通讯作者：
Bollati V
中科院分区：
文献类型：
--
作者：
Angelici L;Piola M;Cavalleri T;Randi G;Cortini F;Bergamaschi R;Baccarelli AA;Bertazzi PA;Pesatori AC;Bollati V
多发性硬化症（MS）是中枢神经系统的慢性、炎性、脱髓鞘疾病，其特征在于导致轻度至重度残疾的炎症的反复发作。暴露于空气中的颗粒物（PM）与全身炎症反应和神经炎症的急性增加有关。在本研究中，我们假设暴露于直径< 10 µm的PM（PM10）可能会增加MS相关住院的发生率。我们从研究区域的53个监测点获得了PM10的日浓度，并通过意大利伦巴第大区2001年至2009年的入院-出院记录确定了8287例MS相关住院病例。我们使用泊松回归分析来研究暴露于PM10和住院风险之间的关联。MS复发住院的RR较高与不同时间间隔暴露于PM10相关。在第0天至第7天暴露期间，发现PM10对MS住院的最大影响：在PM10水平处于最高四分位数的一周前，MS住院增加了42%（95%CI 1.39-1.45）。四分位数间趋势的p值< 0.001。这些数据支持这一假设，即空气污染可能在确定MS的发生和复发中发挥作用。我们的发现可能为确定MS的致病机制开辟新的途径，并可能应用于其他自身免疫性疾病。
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system, characterized by recurrent relapses of inflammation that cause mild to severe disability. Exposure to airborne particulate matter (PM) has been associated with acute increases in systemic inflammatory responses and neuroinflammation. In the present study, we hypothesize that exposure to PM < 10 µm in diameter (PM10) might increase the occurrence of MS-related hospitalizations. We obtained daily concentrations of PM10 from 53 monitoring sites covering the study area and we identified 8287 MS-related hospitalization through hospital admission-discharge records of the Lombardy region, Italy, between 2001 and 2009. We used a Poisson regression analysis to investigate the association between exposure to PM10 and risk of hospitalization. A higher RR of hospital admission for MS relapse was associated with exposure to PM10 at different time intervals. The maximum effect of PM10 on MS hospitalization was found for exposure between days 0 and 7: Hospital admission for MS increased 42% (95%CI 1.39–1.45) on the days preceded by one week with PM10 levels in the highest quartile. The p-value for trend across quartiles was < 0.001. These data support the hypothesis that air pollution may have a role in determining MS occurrence and relapses. Our findings could open new avenues for determining the pathogenic mechanisms of MS and potentially be applied to other autoimmune diseases.