GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1
GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1
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DOI：
10.1128/jvi.01522-06
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发表时间：
2007-02-01
影响因子：
5.4
通讯作者：
Jacobson, Steven
中科院分区：
文献类型：
--
作者：
Takenouchi, Norihiro;Jones, Kathryn S.;Jacobson, Steven
GLUT 1最近被认为是人类T细胞白血病病毒1型（HTLV-1）的结合受体。我们使用了一种新的短期测定来确定GLUT 1在细胞间传递中的作用。虽然细胞表面GLUT 1水平的增加增强了HTLV-1的转移，但有效的病毒传播在很大程度上与靶细胞上的硫酸乙酰肝素蛋白聚糖（HSPG）表达相关。此外，由于对HTLV-1感染敏感的活化的CD 4（+）T细胞和脐带血淋巴细胞表达不可检测水平的表面GLUT 1，这些结果表明GLUT 1和HSPG对于HTLV-1的有效细胞间传播是重要的，但引起了对GLUT 1作为HTLV-1主要结合受体的作用的关注。
GLUT1 has recently been suggested to be a binding receptor for human T-cell leukemia virus type 1 (HTLV-1). We used a novel, short-term assay to define the role of GLUT1 in cell-to-cell transmission. Although increasing cell surface levels of GLUT1 enhanced HTLV-1 transfer, efficient virus spread correlated largely with heparan sulfate proteoglycan (HSPG) expression on target cells. Moreover, since activated CD4(+) T cells and cord blood lymphocytes that are susceptible to HTLV-1 infection expressed undetectable levels of surface GLUT1, these results indicate that GLUT1 and HSPGs are important for efficient cell-to-cell transmission of HTLV-1 but raise concerns on the role of GLUT1 as the HTLV-1 primary binding receptor.