Interhemispheric functional connectivity following prenatal or perinatal brain injury predicts receptive language outcome.
Interhemispheric functional connectivity following prenatal or perinatal brain injury predicts receptive language outcome.
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DOI：
10.1523/jneurosci.2851-12.2013
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发表时间：
2013-03-27
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影响因子：
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通讯作者：
Small SL
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文献类型：
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作者：
Dick AS;Raja Beharelle A;Solodkin A;Small SL
早期脑损伤改变了大脑半球之间的结构和功能连接。尽管越来越多的知识，个人半球的贡献，从这种损伤的恢复，我们知道很少关于他们的相互作用如何影响这一进程。在本研究中，我们将大脑半球间的结构和功能连接与早期左半球卒中后的接受性语言结果联系起来。我们使用功能性磁共振成像研究了14名新生儿脑损伤患者和25名年龄匹配的对照组在被动故事理解过程中的表现。在结构连接方面，我们发现胼胝体体积的增加预示着良好的接受性语言结果，但这并不特定于受伤的人。相比之下，我们发现，增加后上级颞回半球间的功能连接在故事理解预测更好的接受语言的表现在早期脑损伤的人，但在典型的控制性能较差。这表明，大脑半球间的功能连接是一个潜在的补偿机制后，早期损伤。此外，这种结果模式表明，流行的观点是早期左半球损伤后更好的语言结果依赖于对侧半球的贡献（即，“右半球接管”理论）。这种结果模式也具有区域特异性;角回的连通性预测两组的表现较差，与脑损伤无关。这些结果提出了一个复杂的图片恢复在某些情况下，这种恢复依赖于增加合作之间的受伤的半球和同源区域的对侧半球，但在其他情况下，相反的似乎举行。
Early brain injury alters both structural and functional connectivity between the cerebral hemispheres. Despite increasing knowledge on the individual hemispheric contributions to recovery from such injury, we know very little about how their interactions affect this process. In the present study, we related interhemispheric structural and functional connectivity to receptive language outcome following early left hemisphere stroke. We used functional magnetic resonance imaging to study 14 people with neonatal brain injury, and 25 age-matched controls during passive story comprehension. With respect to structural connectivity, we found that increased volume of the corpus callosum predicted good receptive language outcome, but that this is not specific to people with injury. By contrast, we found that increased posterior superior temporal gyrus interhemispheric functional connectivity during story comprehension predicted better receptive language performance in people with early brain injury, but worse performance in typical controls. This suggests that interhemispheric functional connectivity is one potential compensatory mechanism following early injury. Further, this pattern of results suggests refinement of the prevailing notion that better language outcome following early left hemisphere injury relies on the contribution of the contralesional hemisphere (i.e., the “right-hemisphere-take-over” theory). This pattern of results was also regionally specific; connectivity of the angular gyrus predicted poorer performance in both groups, independent of brain injury. These results present a complex picture of recovery—in some cases, such recovery relies on increased cooperation between the injured hemisphere and homologous regions in the contralesional hemisphere, but in other cases, the opposite appears to hold.