Numerical investigation on the flow characteristics and aerodynamic force of the upper airway of patient with obstructive sleep apnea using computational fluid dynamics
Numerical investigation on the flow characteristics and aerodynamic force of the upper airway of patient with obstructive sleep apnea using computational fluid dynamics
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DOI：
10.1016/j.medengphy.2006.08.017
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发表时间：
2007-07-01
影响因子：
2.2
通讯作者：
Sung, Sang-Jin
中科院分区：
文献类型：
--
作者：
Jeong, Soo-Jin;Kim, Woo-Seung;Sung, Sang-Jin
建立数学模型来预测阻塞性睡眠呼吸暂停所产生的异常血流特征是了解阻塞性睡眠呼吸暂停（OSA）疾病病理生理学的重要一步。本研究提供了阻塞性睡眠呼吸暂停患者咽气道流量的详细计算。为了实现这一目标，使用OSA患者三维计算机断层扫描（CT）图像的原始数据构建了计算流体动力学模型。为了再现咽部气道中从层流到湍流的重要转变，我们采用了低雷诺数k-epsilon模型，并利用先前的公开文献成功验证了该模型。结果表明，OSA患者咽部气道内的流动是由腭咽处的面积限制形成的湍流射流。这种湍流射流在腭咽附近引起更高的剪切力和压力。从结果可以推断，OSA患者咽部气道最易折叠的区域是腔内压力最小、气动力最大的腭咽部。(c) 2006年ipm。Elsevier Ltd.出版。版权所有。
Developing a mathematical model to predict the abnormal flow characteristics that are produced by obstructive sleep apnea is an important step in learning the pathophysiology of the obstructive sleep apnea (OSA) disease.The present study provides detailed calculations of flow in the pharyngeal airway of a patient with obstructive sleep apnea. To achieve this goal, a computational fluid dynamics model was constructed using raw data from three-dimensional computed tomogram (CT) images of an OSA patient.To reproduce the important transition from laminar to turbulent flow in the pharyngeal airway, the low Reynolds number k-epsilon model was adopted and successfully validated using previous open literature.The results show that the flow in the pharyngeal airway of patients with OSA comprises a turbulent jet formed by area restriction at the velopharynx. This turbulent jet causes higher shear and pressure forces in the vicinity of the velopharynx.From the results, It may be deduced that the most collapsible area in the pharyngeal airway of OSA patients is the velopharynx where minimum intraluminal pressure and maximum aerodynamic force lie. (c) 2006 IPEM. Published by Elsevier Ltd. All rights reserved.