Mammographic parenchymal patterns as indicators of breast cancer risk.
Mammographic parenchymal patterns as indicators of breast cancer risk.
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DOI：
10.1093/oxfordjournals.aje.a115163
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发表时间：
1989-03
影响因子：
5
通讯作者：
A. Saftlas;J. Wolfe;R. Hoover;L. Brinton;C. Schairer;M. Salane;M. Szklo
中科院分区：
文献类型：
--
作者：
A. Saftlas;J. Wolfe;R. Hoover;L. Brinton;C. Schairer;M. Salane;M. Szklo
乳腺X线摄影实质模式被建议作为乳腺癌风险的指标。然而，很少有对照良好的研究使用诊断前乳房X光检查来确定模式分类。作者研究了来自乳腺癌检测和示范项目 25 个筛查中心的 266 例乳腺癌病例和 301 例对照，该项目是 1973 年至 1980 年间进行的一项全国性筛查计划，旨在使用乳腺癌检测前四年拍摄的乳房 X 光照片来评估与乳房 X 线照相模式相关的风险。乳房X线照相图案分类的创始人之一的研究人员（J.N.W.）对病例的癌性乳房和与每个病例匹配的对照同侧乳房的乳房X线照片进行盲目评估。与具有 N1 模式的女性相比，具有 P2 + DY 组合模式的女性患乳腺癌的优势比为 2.8（95% 置信区间 (CI)：1.6-5.1）。这种相对风险的估计与其他公认的乳腺癌风险因素相关的风险相当。与无乳腺癌家族史的 N1 女性相比，有乳腺癌一级家族史的 P2 + DY 女性的比值比为 5.5（95% CI：2.6-11.8）。这些数据提供了额外的证据，表明乳房X线照相模式是乳腺癌后续发展的指标，特别是在具有这种恶性肿瘤一级家族史的女性中。
Mammographic parenchymal patterns have been suggested as indicators of breast cancer risk. However, few well-controlled studies have used prediagnostic mammograms to determine the pattern classification. The authors studied 266 cases of breast cancer and 301 controls from 25 screening centers of the Breast Cancer Detection and Demonstration Project, a nationwide screening program conducted between 1973 and 1980 to evaluate the risk associated with mammographic patterns using mammograms taken four years before the detection of breast cancer. Mammograms of the cancerous breast of cases and of the ipsilateral breast in the control matched to each case were blindly assessed by one of the investigators (J.N.W.), originator of the mammographic pattern classification. The breast cancer odds ratio among women with the combined P2 + DY patterns, compared with women with the N1 pattern, was 2.8 (95% confidence interval (CI): 1.6-5.1). This estimate of relative risk was comparable with the risk associated with other recognized breast cancer risk factors. The odds ratio among P2 + DY women with a first-degree family history of breast cancer was 5.5 (95% CI: 2.6-11.8) compared with N1 women without a family history. These data provide additional evidence that mammographic patterns are indicators for subsequent development of breast cancer, particularly among women with a first-degree family history of this malignancy.