Spatial organization of organelles in fungi: Insights from mathematical modelling.
Spatial organization of organelles in fungi: Insights from mathematical modelling.
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DOI：
10.1016/j.fgb.2017.03.006
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Steinberg G
中科院分区：
文献类型：
--
作者：
Lin C;Steinberg G
动力蛋白运动模型揭示了动力蛋白彗星形成的随机作用。建模有助于阐明早期内体的空间组织机制。核糖体和过氧化物酶体的分布是扩散和定向运动的结合。细胞系统中的数学建模旨在以定量的方式描述生物过程。最准确的建模是基于可靠的实验数据。在这里，我们回顾了最近的进展，在理论上的描述电机的行为，早期内体运动，核糖体分布和过氧化物酶体运输的真菌模型系统玉米黑粉菌，并说明在我们寻求了解丝状真菌膜贩运的分子细节和细胞作用的建模的力量。
Modelling of dynein motility reveals a stochastic role in dynein comet formation. Modelling helps to elucidate mechanisms in spatial organization of early endosomes. A combination of diffusion and directed motion distributes ribosomes and peroxisomes. Mathematical modelling in cellular systems aims to describe biological processes in a quantitative manner. Most accurate modelling is based on robust experimental data. Here we review recent progress in the theoretical description of motor behaviour, early endosome motility, ribosome distribution and peroxisome transport in the fungal model system Ustilago maydis and illustrate the power of modelling in our quest to understand molecular details and cellular roles of membrane trafficking in filamentous fungi.