Age-related differences in volumetric bone mineral density, microarchitecture, and bone strength of distal radius and tibia in Chinese women: a high-resolution pQCT reference database study
Age-related differences in volumetric bone mineral density, microarchitecture, and bone strength of distal radius and tibia in Chinese women: a high-resolution pQCT reference database study
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DOI：
10.1007/s00198-015-3045-x
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发表时间：
2015-06-01
影响因子：
4
通讯作者：
Qin, L.
中科院分区：
文献类型：
--
作者：
Hung, V. W. Y.;Zhu, T. Y.;Qin, L.
在一个包含393名中国女性的队列中，通过使用高分辨率外周定量计算机断层扫描（HR-pQCT），我们发现中年后发生了显著的皮质骨丢失。皮质孔隙度的显著增加开始于第五个十年，但在第六个十年之前达到一个平台。小梁骨丢失在青年期已经很明显，并在整个生命过程中持续存在。引言本研究旨在调查中国女性人群中与年龄相关的体积骨矿物质密度（vBMD）、微结构和外周骨骼估计骨强度的差异。结果年龄相关性差异最大的预测指标是骨皮质孔隙度（Ct.Po），在成年期，骨皮质孔隙度在桡骨远端和胫骨的差异分别超过4倍和2倍。在这两个网站，皮质骨面积，vBMD和厚度显示显着的二次相关与年龄显着下降后开始中年。年龄在50 - 57岁之间的Ct.Po变化更加显著（桡骨远端为0.26%/年，胫骨远端为0.54%/年，均为p 0.05）。相比之下，骨小梁vBMD和微结构显示与年龄呈线性相关，在整个成年期观察到显著恶化。骨小梁vBMD和微结构以及Ct.Po的峰值年龄估计为20岁左右，皮质vBMD和微结构的峰值年龄估计为40岁左右。估计刚度和失效载荷达到高峰，在30年代中期在桡骨远端和20岁时在胫骨远端。结论骨相关的差异vBMD和微结构在中国妇女不同的骨隔间。中年后出现明显的皮质骨丢失。显着增加Ct.宝开始在第五个十年，但似乎是在第六个十年前被捕。骨小梁的丢失在青年期就已经很明显，并持续一生。
A Summary In a cohort of 393 Chinese women, by using high-resolution peripheral quantitative computed tomography (HR-pQCT), we found that significant cortical bone loss occurred after midlife. Prominent increase in cortical porosity began at the fifth decade but reached a plateau before the sixth decade. Trabecular bone loss was already evident in young adulthood and continued throughout life.Introduction This study aimed to investigate age-related differences in volumetric bone mineral density (vBMD), microarchitecture, and estimated bone strength at peripheral skeleton in Chinese female population.Methods In a cross-sectional cohort of 393 Chinese women aged 20-90 years, we obtained vBMD, microarchtecture, and micro-finite element-derived bone strength at distal radius and tibia using HR-pQCT.Results The largest predictive age-related difference was found for cortical porosity (Ct.Po) which showed over four-fold and two-fold differences at distal radius and tibia, respectively, over the adulthood. At both sites, cortical bone area, vBMD, and thickness showed significant quadratic association with age with significant decrease beginning after midlife. Change of Ct.Po became more prominent between age of 50 and 57 (0.26 %/year at distal radius, 0.54 %/year at distal tibia, both p 0.05). In contrast, trabecular vBMD and microarchitecture showed linear association with age with significant deterioration observed throughout adulthood. Estimated age of peak was around age of 20 for trabecular vBMD and microarchitecture and Ct.Po and age of 40 for cortical vBMD and microarchitecture. Estimated stiffness and failure load peaked at mid-30s at the distal radius and at age 20 at distal tibia.Conclusions Age-related differences in vBMD and microarchitecture in Chinese women differed by bone compartments. Significant cortical bone loss occurred after midlife. Prominent increase in Ct.Po began at the fifth decade but appeared to be arrested before the sixth decade. Loss of trabecular bone was already evident in young adulthood and continued throughout life.