Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylon-infected Mongolian gerbils
Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylon-infected Mongolian gerbils
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DOI：
10.1016/j.jep.2013.11.040
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发表时间：
2014-02-12
影响因子：
5.4
通讯作者：
Wang, Yuan-Chuen
中科院分区：
文献类型：
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作者：
Kuo, Chao-Hung;Weng, Bi-Chuang;Wang, Yuan-Chuen
民族药理学相关性：芹菜素是最常见的黄酮类化合物之一，在芹菜、欧芹、洋甘菊、西番莲和其他蔬菜和水果中含量丰富。芹菜在东方国家被认为是一种药用蔬菜，传统上用于治疗炎症、肿胀、血压、血脂和牙痛。在这项研究中，我们调查芹菜素治疗幽门螺杆菌引起的萎缩性胃炎和胃癌进展的蒙古沙鼠。材料和方法：5至8周龄的蒙古沙鼠接种幽门螺杆菌4周（萎缩性胃炎组）或与N '-甲基-N'-硝基-N-亚硝基胍（MNNG）（胃癌组）的饮用水，然后休息两周。在第7~32周（萎缩性胃炎组）或第7~52周（胃癌组）给予不同剂量（0-60 mg/kgbw/d）芹菜素。分别于第32周（萎缩性胃炎组）和第52周（萎缩性胃炎组），采用CO2窒息法处死动物。结果：芹菜素（30-60 mg/kgbw/d）能有效降低蒙古沙土鼠萎缩性胃炎（萎缩性胃炎组）和异型增生/胃癌（胃癌组）的发生率。芹菜素治疗（60 mg/kgbw/d）可显著降低幽门螺杆菌在萎缩性胃炎和胃癌蒙古沙土鼠中的定植率和幽门螺杆菌诱导的中性粒细胞和单核细胞浸润及萎缩性胃炎的组织学改变。结论：芹菜素具有显著的抑制幽门螺杆菌诱导的萎缩性胃炎和胃癌进展的能力，并具有较强的抗胃癌活性。(c)2013爱思唯尔爱尔兰有限公司版权所有。
Ethnopharmacological relevance: Apigenin, one of the most common flavonoids, is abundant in celery, parsley, chamomile, passionflower, and other vegetables and fruits. Celery is recognized as a medicinal vegetable in Oriental countries to traditionally treat inflammation, swelling, blood pressure, serum lipid, and toothache. In this study, we investigated apigenin treatment effects on Helicobacter pylori-induced atrophic gastritis and gastric cancer progression in Mongolian gerbils.Materials and methods: Five to eight-week-old Mongolian gerbils were inoculated with Helicobacter pylori for four weeks without (atrophic gastritis group) or with N'-methyl-N'-nitro-N-nitroso-guanidine (MNNG) (gastric cancer group) in drinking water, and were then rested for two weeks. During the 7th-32th (atrophic gastritis group) or the 7th-52th (gastric cancer group) weeks, they were given various doses (0-60 mg/kgbw/day) of apigenin. At the end of the 32th (atrophic gastritis group) or the 52th (atrophic gastritis group) week, all Mongolian gerbils were sacrificed using the CO2 asphyxia method. The histological changes of Helicobacter pylori colonization, neutrophil and monocyte infiltrations, and atrophic gastritis in both atrophic gastritis and gastric cancer Mongolian gerbils were examined using immunohistochemistry stain and Sydney System scoring.Results: Apigenin treatments (30-60 mg/kgbw/day) effectively decreased atrophic gastritis (atrophic gastritis group) and dysplasia/gastric cancer (gastric cancer group) rates in Mongolian gerbils. Apigenin treatment (60 mg/kgbw/day) significantly decreased Helicobacter pylori colonization and Helicobacter pylori-induced histological changes of neutrophil and monocyte infiltrations and atrophic gastritis in both atrophic gastritis and gastric cancer Mongolian gerbils.Conclusions: Apigenin has the remarkable ability to inhibit Helicobacter pylori-induced atrophic gastritis and gastric cancer progression as well as possessing potent anti-gastric cancer activity. (c) 2013 Elsevier Ireland Ltd. All rights reserved.