The anti-nociceptive efficacy of low dose intramuscular xylazine in lambs
The anti-nociceptive efficacy of low dose intramuscular xylazine in lambs
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DOI：
10.1053/rvsc.2000.0439
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发表时间：
2001-02-01
影响因子：
2.4
通讯作者：
Upton, RN
中科院分区：
文献类型：
--
作者：
Grant, C;Upton, RN
采用电伤害感受测试方法，对7只4-6周龄羔羊肌注甲苯噻嗪50 μg kg(-1)的抗伤害感受作用进行了检测。羔羊抗伤害感受从平均基线 5.88+/-0.72 mA 增加到给药后 21 分钟 (平均值+/-SEM) 的平均峰值 13.662+/-1.49 mA，并在实验期间（60 分钟）保持高于基线。从给予甲苯噻嗪后 5 分钟起，所有值均显着高于基线。这些数据还与之前发表的接受相同治疗的成年羊的数据进行了比较。成年组或羔羊组之间的镇痛反应没有差异，这表明甲苯噻嗪的剂量需求与体重成正比，并且在此范围内不受年龄的影响。这些发现支持使用甲苯噻嗪作为绵羊的有效镇痛剂，成年绵羊和羔羊之间具有可比的效果和一致的单位体重剂量要求。 (C) 2001 年哈考特出版有限公司。
The anti-nociceptive effects of 50 mug kg(-1) of intramuscular xylazine were examined in seven lambs of 4-6 weeks of age using an electrical nociceptive testing method. Lamb anti-nociception increased from an average baseline of 5.88+/-0.72 mA to an average peak value of 13.662+/-1.49 mA at 21 minutes (mean+/-SEM) after the dose, and remained above baseline for the duration of the experimental period (60 minutes). All values were significantly above baseline from 5 minutes post-xylazine administration onwards. These data were also compared with previously published data from adult sheep undergoing the same treatment. There were no differences in the analgesic response between the adult or lamb groups suggesting xylazine dose requirements scale with bodyweight and are unaffected by age over this range. These findings support the use of xylazine as an effective analgesic in sheep with comparable effects and consistent dosing requirements per unit body weight between adult sheep and lambs. (C) 2001 Harcourt Publishers Ltd.