Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography.
Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography.
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DOI：
10.1016/j.ophtha.2008.10.006
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发表时间：
2009-03
期刊：
影响因子：
13.7
通讯作者：
Toth CA
中科院分区：
文献类型：
--
作者：
Schuman SG;Koreishi AF;Farsiu S;Jung SH;Izatt JA;Toth CA
通过光谱域光学相干断层扫描（SDOCT）检测老年性黄斑变性（AMD）患者神经感觉视网膜的变化。定量成像生物标志物可能有助于确定进展风险，并为AMD提供更好的治疗选择。评估AMD患者SDOCT检测的横断面病例对照研究。12例非血管性黄斑变性和血管性黄斑变性患者的17只眼睛和10例年龄匹配的对照患者的17只眼睛。SDOCT成像横跨研究眼的中央凹，进行多次10至12毫米扫描，每次扫描1000次a扫描。在总结的SDOCT扫描中，单个视网膜层的高度要么高于眼球，要么在对照眼的相应位置。二次测量：感光层（PRL）面积、视网膜内面积、视网膜色素上皮(RPE)/膜面积。视网膜层的质变。与对照组相似位置的PRL厚度相比，dren的PRL厚度平均减少了27.5%，差异的发现是有效且显著的（P=0.004）。在47%的眼睛中，至少有一个区域的光感受器外节缺失。尽管PRL变薄，但视网膜内部厚度保持不变。我们观察到两种类型的高反射异常的神经感觉视网膜。首先，明显的高反射斑点模式出现在41%的AMD眼睛，而在对照眼睛中从未出现过。其次，在67%的AMD眼睛中，drusen上方的光感受器核层中存在明显的高反射雾，而在18%的对照眼睛（无drusen）中，光感受器核层中存在更细微的雾。在本研究中使用SDOCT，我们可以很容易地检测和测量患者PRL的变化。dren上PRL厚度减少提示细胞丢失导致视觉功能下降的退行性过程。drusen上的高反射灶可能代表疾病的进展，RPE细胞迁移到视网膜，可能有光感受器变性或胶质瘢痕形成。纵向研究使用SDOCT检查和测量神经感觉视网膜上的囊肿将解决这些退行性改变相对于囊肿形成的时间表。
To detect changes in the neurosensory retina from spectral domain optical coherence tomography (SDOCT) imaging over drusen in age-related macular degeneration (AMD). Quantitative imaging biomarkers may aid in defining risk of progression and lead to better treatment options for AMD. Cross-sectional, case-control study evaluating SDOCT testing in AMD. Seventeen eyes of twelve subjects with non-neovascular AMD and drusen and seventeen eyes of ten age-matched control subjects. SDOCT imaging across the fovea in the study eye with multiple 10 to 12 mm scans of 1000 A-scans each. In summed SDOCT scans, the height of individual retinal layers either over drusen or at corresponding locations in the control eye. Secondary measure: Photoreceptor layer (PRL) area, inner retinal area and retinal pigment epithelium (RPE)/drusen area. Qualitative changes in retinal layers over drusen. The PRL was thinned over 97% of drusen, the average PRL thickness was reduced by 27.5% over drusen compared to over a similar location in controls, and the finding of a difference was valid and significant (P=0.004). Photoreceptor outer segments were absent over at least one druse in 47% of eyes.. Despite thinning of the PRL, inner retinal thickness remained unchanged. We observed two types of hyper-reflective abnormalities in the neurosensory retina over drusen. First, distinct hyper-reflective speckled patterns occurred over drusen in 41% of AMD eyes and never in control eyes. Second, a prominent hyper-reflective haze was present in the photoreceptor nuclear layer over drusen in 67% of AMD eyes and more subtly in the photoreceptor nuclear layer in 18% of control eyes (no drusen). With SDOCT as used in this study, we can easily detect and measure changes in PRL over drusen. Decreased PRL thickness over drusen suggests a degenerative process with cell loss leading to decreased visual function. The hyper-reflective foci overlying drusen are likely to represent progression of disease with RPE cell migration into the retina and possible photoreceptor degeneration or glial scar formation. A longitudinal study using SDOCT to examine and measure the neurosensory retina over drusen will resolve the timeline of these degenerative changes relative to druse formation.
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影响因子：
--
作者：
Kassoff, A;Kassoff, J;Chew, EY
通讯作者：
Chew, EY
影响因子：
4.2
作者：
Holz, FG;Pauleikhoff, D;Bird, AC
通讯作者：
Bird, AC
影响因子：
3.7
作者：
Francis PJ;Schultz DW;Hamon S;Ott J;Weleber RG;Klein ML
通讯作者：
Klein ML
影响因子：
4.4
作者：
Johnson, PT;Lewis, GP;Johnson, LV
通讯作者：
Johnson, LV
影响因子：
13.7
作者：
Klein, Ronald;Klein, Barbara E. K.;Gangnon, Ronald E.
通讯作者：
Gangnon, Ronald E.