Intrafascicular stimulation of monkey arm nerves evokes coordinated grasp and sensory responses
Intrafascicular stimulation of monkey arm nerves evokes coordinated grasp and sensory responses
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DOI：
10.1152/jn.00688.2011
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发表时间：
2013-01-01
影响因子：
2.5
通讯作者：
Clark, Gregory A.
中科院分区：
文献类型：
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作者：
Ledbetter, Noah M.;Ethier, Christian;Clark, Gregory A.
Ledbetter NM，Mr. C，Oby ER，Hiatt SD，怀尔德AM，Ko JH，Agnew SP，米勒LE，克拉克GA.猴臂神经束内刺激引起协调的抓握和感觉反应。J Neurophysiol 109：580-590，2013.首次发表于2012年10月17日; doi：10.1152/jn.00688.2011.-周围神经植入高计数微电极阵列可恢复脊髓损伤后的运动功能或肢体丧失后的感觉功能。在这项研究中，我们在异氟烷麻醉下将犹他州倾斜电极阵列（USEA）植入恒河猴（n = 4）臂神经手肘或肩部神经束内。输入-输出曲线表明，每个臂神经中的脉冲宽度调制单电极刺激可以招募单个肌肉，而很少或没有招募其他肌肉。刺激列车诱发特定的，自然的，手的运动，这可以通过多电极刺激相结合，以引起协调的权力或捏抓。刺激还在初级躯体感觉皮层中引起短潜伏期诱发电位（EPs），其可用于提供来自假肢的感觉反馈。这些结果表明，高分辨率，高通道数接口的周围神经系统恢复手功能后，神经损伤或中断或检查神经结构。
Ledbetter NM, Ethier C, Oby ER, Hiatt SD, Wilder AM, Ko JH, Agnew SP, Miller LE, Clark GA. Intrafascicular stimulation of monkey arm nerves evokes coordinated grasp and sensory responses. J Neurophysiol 109: 580-590, 2013. First published October 17, 2012; doi:10.1152/jn.00688.2011.-High-count microelectrode arrays implanted in peripheral nerves could restore motor function after spinal cord injury or sensory function after limb loss. In this study, we implanted Utah Slanted Electrode Arrays (USEAs) intrafascicularly at the elbow or shoulder in arm nerves of rhesus monkeys (n = 4) under isoflurane anesthesia. Input-output curves indicated that pulse-width-modulated single-electrode stimulation in each arm nerve could recruit single muscles with little or no recruitment of other muscles. Stimulus trains evoked specific, natural, hand movements, which could be combined via multielectrode stimulation to elicit coordinated power or pinch grasp. Stimulation also elicited short-latency evoked potentials (EPs) in primary somatosensory cortex, which might be used to provide sensory feedback from a prosthetic limb. These results demonstrate a high-resolution, high-channel-count interface to the peripheral nervous system for restoring hand function after neural injury or disruption or for examining nerve structure.