Taurine activates glycine and -aminobutyric acid A receptors in rat substantia gelatinosa neurons
Taurine activates glycine and -aminobutyric acid A receptors in rat substantia gelatinosa neurons
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DOI：
10.1097/wnr.0b013e3282f50c90
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发表时间：
2008-02
期刊：
影响因子：
1.7
通讯作者：
Jun Wu;T. Kohno;Stefan K. Georgiev;Miho Ikoma;Hideaki Ishii;A. Petrenko;H. Baba
中科院分区：
文献类型：
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作者：
Jun Wu;T. Kohno;Stefan K. Georgiev;Miho Ikoma;Hideaki Ishii;A. Petrenko;H. Baba
牛磺酸被认为可以调节脊髓水平的伤害性信息。本研究采用全细胞膜片钳技术研究了牛磺酸在成年大鼠胶状质(SG)神经元上的药理作用。我们发现牛磺酸似乎比甘氨酸对SG神经元上的甘氨酸受体有更高的作用。氯化物电导的增加是牛磺酸诱导电流的原因。0.3 mM的牛磺酸激活甘氨酸受体，而3 mM的牛磺酸同时激活甘氨酸和-氨基丁酸A受体。牛磺酸和甘氨酸共同作用所激活的电流具有交叉抑制作用。综上所述，这些结果表明，牛磺酸可能是另一种重要的神经递质或调节剂，可能参与抗伤害性感觉。
Taurine has been suggested to modulate nociceptive information at the spinal cord level. In this study, the pharmacological properties of taurine were investigated in adult rat substantia gelatinosa (SG) neurons using whole-cell patch-clamp method. We found that taurine seemed to have higher efficacy than glycine on glycine receptors in SG neurons. An increase in chloride conductance was responsible for taurine-induced currents. Taurine at 0.3 mM activated glycine receptors, whereas at 3 mM activated both glycine and -aminobutyric acid A receptors. The currents activated by coapplication of taurine and glycine are cross inhibitive. Altogether these results show that taurine might represent another important neurotransmitter or modulator in SG neurons, which may be involved in antinociception.