Adipose tissue spexin in physical exercise and age-associated diseases
Adipose tissue spexin in physical exercise and age-associated diseases
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脂肪组织 spexin 在体育锻炼和年龄相关疾病中的作用
DOI：
10.1016/j.arr.2021.101509
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发表时间：
2021-11-18
影响因子：
13.1
通讯作者：
Zhang, Zhenwen
中科院分区：
文献类型：
--
作者：
Fang, Penghua;Ge, Ran;Zhang, Zhenwen
已知次优生活方式（缺乏运动和久坐行为和/或高热量饮食）与发生年龄相关疾病（如肥胖和T2 DM）的倾向增加之间存在强相关性。体育锻炼可以减轻肥胖引起的胰岛素抵抗和2型糖尿病，但其确切机制尚不完全清楚。肥胖者脂肪组织内分泌紊乱在胰岛素抵抗的发生发展中起重要作用。在这方面，spexin最近被描述为在肥胖诱导的胰岛素抵抗和T2 DM的病理生理学中起重要作用的脂肪因子。在肥胖状态下，脂肪组织spexin的表达减少，诱导脂肪组织和骨骼肌更容易发生胰岛素抵抗。新的证据指出，运动可以增加spexin的表达。因此，spexin可能是运动改善肥胖诱导的胰岛素抵抗和2型糖尿病的潜在介质，即运动对胰岛素敏感性的有益作用至少部分由spexin介导。本文综述了我们和其他人最近关于肥胖对脂肪组织spexin诱导的影响的研究，沿着运动在肥胖背景下对这种反应的潜在影响，并提供了一个新的见解运动，spexin和T2 DM之间的多元关系。因此，应该考虑到spexin和运动训练的组合是年龄相关疾病的有效治疗策略。
It is known that a strong association exists between a suboptimal lifestyle (physical inactivity and sedentary behavior and/or high calorie diet) and increased propensity of developing age-associated diseases, such as obesity and T2DM. Physical exercise can alleviate obesity-induced insulin resistance and T2DM, however, the precise mechanism for this outcome is not fully understood. The endocrine disorder of adipose tissue in obesity plays a critical role in the development of insulin resistance. In this regard, spexin has been recently described as an adipokine that plays an important role in the pathophysiology of obesity-induced insulin resistance and T2DM. In obese states, expression of adipose tissue spexin is reduced, inducing the adipose tissue and skeletal muscle more susceptible to insulin resistance. Emerging evidences point out that exercise can increase spexin expression. In return, spexin could exert the exercise-protective roles to ameliorate insulin resistance, suggesting that spexin is a potential mediator for exercise to ameliorate obesity-induced insulin resistance and T2DM, namely, the beneficial effect of exercise on insulin sensitivity is at least partly mediated by spexin. This review summarizes our and others' recent studies regarding the effects of obesity on adipose tissue spexin induction, along with the potential effect of exercise on this response in obese context, and provides a new insight into the multivariate relationship among exercise, spexin and T2DM. It should be therefore taken into account that a combination of spexin and exercise training is an effective therapeutic strategy for age-associated diseases.