Vitamin D metabolism is altered in Asian Indians in the southern United States: a clinical research center study.
Vitamin D metabolism is altered in Asian Indians in the southern United States: a clinical research center study.
复制标题
DOI：
10.1210/jcem.83.1.4514
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Emmanuel M. K. Awumey;Devashis A. Mitra;Bruce W. Hollis;Rajiv Kumar;Norman H. Bell
中科院分区：
文献类型：
--
作者：
Emmanuel M. K. Awumey;Devashis A. Mitra;Bruce W. Hollis;Rajiv Kumar;Norman H. Bell
移民到北方欧洲的亚洲印度人血清25-羟维生素D [25（OH）D]低于高加索人，他们会出现维生素D缺乏症、佝偻病和骨软化症。我们研究了维生素D代谢，25（OH）D3对维生素D代谢和25（OH）D-24-羟化酶（25（OH）D降解的限速酶）活性的影响，从培养的亚洲印第安人皮肤成纤维细胞中，并将其与美国南部高加索人培养的皮肤成纤维细胞进行比较。正常受试者，年龄20-40岁，入住代谢病房2.5天，每天给予含有400毫克钙和900毫克磷的饮食。血清维生素D，血清25（OH）D，尿钙，尿磷显着较低，而血清免疫反应全段甲状旁腺激素（PTH）和血清1，25-二羟维生素D [1，25（OH）2D]显着高于亚洲印度人比高加索人。在亚洲印第安人中，25（OH）D3可增加血清25（OH）D和尿钙，但不改变血清PTH或血清1，25（OH）2D。在培养的皮肤成纤维细胞，Emax和Vmax的25（OH）D-24-羟化酶活性显着较高的亚洲印度人。总之，在亚洲印第安人血清维生素D和25（OH）D显着减少，改变维生素D代谢仅部分逆转25（OH）D3，和25（OH）D-24-羟化酶活性在培养的皮肤成纤维细胞显着增加。因此，居住在美国的亚洲印度人有患维生素D缺乏症、佝偻病和骨软化症的风险。
Asian Indians who immigrate to northern Europe have lower serum 25-hydroxyvitamin D [25(OH)D] than Caucasians, and they develop vitamin D deficiency, rickets, and osteomalacia. We investigated vitamin D metabolism, the effects of 25(OH)D3 on vitamin D metabolism and activity of 25(OH) D-24-hydroxylase, the rate-limiting enzyme for degradation of 25(OH)D, from cultured skin fibroblasts of Asian Indians and compared them with cultured skin fibroblasts of Caucasians in the southern United States. Normal subjects, ages 20-40 yr, were admitted to a metabolic ward for 2.5 days and given a daily diet containing 400 mg calcium and 900 mg phosphorus. Serum vitamin D, serum 25(OH)D, urinary calcium, and urinary phosphorus were significantly lower, whereas serum immunoreactive intact parathyroid hormone (PTH) and serum 1,25-dihydroxyvitamin D [1,25(OH)2D] were significantly higher in Asian Indians than in Caucasians. Administration of 25(OH)D3 increased serum 25(OH)D and urinary calcium but did not change serum PTH or serum 1,25(OH)2D in Asian Indians. In cultured skin fibroblasts, Emax and Vmax of 25(OH)D-24-hydroxylase activity were significantly higher in Asian Indians. In summary, in Asian Indians serum vitamin D and 25(OH)D are markedly reduced, altered vitamin D metabolism is only partially reversed by 25(OH)D3, and 25(OH)D-24-hydroxylase activity in cultured skin fibroblasts is markedly increased. Thus, Asian Indians residing in the U.S. are at risk for developing vitamin D deficiency, rickets, and osteomalacia.