Reduction of the Number of Live Animals Used for Microsurgical Skill Acquisition: An Experimental Randomized Noninferiority Trial.
Reduction of the Number of Live Animals Used for Microsurgical Skill Acquisition: An Experimental Randomized Noninferiority Trial.
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DOI：
10.1055/s-0042-1750422
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发表时间：
2022-10
影响因子：
2.1
通讯作者：
Volovici, Victor
中科院分区：
文献类型：
--
作者：
Esanu, Victor;Stoia, Alexandra I.;Dindelegan, George C.;Colosi, Horatiu A.;Dindelegan, Maximilian G.;Volovici, Victor
关键词：
几十年来，活体动物一直被用作培养外科技能的众多训练模型之一。显微外科尤其依赖于使用活体动物模型，尤其是大鼠（小鼠模型）进行技能获取和维持的培训。目前正在努力减少为实现这一目标而牺牲的老鼠数量。一组具有最低显微外科经验的学生在完成基础显微外科课程后，被随机分为三个相等的组，所有三组都接受为期 24 周的标准训练计划，该计划基于低保真度和中保真度训练模型以及标准化的小鼠训练日。除了标准训练方案外，每位参与者每 4、6 或 8 周对活体大鼠进行补充训练。根据培训计划，这些程序已在鸡腿、花瓣和大鼠上进行，每个程序都使用经过验证的模型和量表进行盲目评估和评估。主要评估结果是每组大鼠最终进行的 SMaRT 量表结果，测试的假设为非劣效性之一。次要结果由最终大鼠吻合时间、最终鸡腿吻合结果和时间以及最终花瓣评分表示。第 24 周后，根据上述手术结果衡量，三组之间的显微手术技能没有差异。所有参与者在研究期间均显着改善（SMaRT 量表平均 (SD) 19 ±4) 分），组间无显着差异，p<0.001 为非劣效性。基于低保真度和中保真度模型的训练方案，加上每 8 周对活体大鼠进行训练，不劣于每 6 周使用活体大鼠的训练方案，也不劣于每 4 周使用活体大鼠的训练方案。
Live animals have been used for decades as one of the many training models for developing surgical skills. Microsurgery in particular relies on training for skill acquisition and maintenance, using live animal models, especially rats (murine models). Efforts are underway to reduce the number of rats sacrificed to achieve this objective. A group of students with minimal microsurgical experience, after having gone through a basic microsurgical course, were randomly split into three equal groups, all three groups following a 24-week standard training program based on low- and medium-fidelity training models with standardized murine training days. In addition to the standard training regimen, each participant carried out supplementary training on live rats every 4, 6, or 8 weeks. According to the training program, the procedures have been performed on chicken legs, flower petals and rats, each procedure being blindly assessed and evaluated using validated models and scales. The primary evaluated outcome was the SMaRT scale result of the final rat anastomosis performed by each group, for which the tested hypothesis was one of non-inferiority. The secondary outcomes were represented by the final rat anastomosis time, final chicken leg anastomosis result and time, and the final petal score. After the 24th week, no differences were observed between the three groups regarding their microsurgical skills, as measured by the aforementioned surgical outcomes. All participants improved significantly during the study (mean (SD) 19 ±4) points on the SMaRT scale), with no significant differences between the groups, p<0.001 for non-inferiority. A training regimen based on low- and moderate-fidelity models, with the addition of training on a live rat every 8 weeks was non-inferior to a training regimen that used a live rat every 6 weeks and also non-inferior to a training regimen that used a live rat every 4 weeks.
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影响因子：
2.1
作者：
Boecker, Arne;Kornmann, Jonas;Hirche, Christoph
通讯作者：
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DOI：
10.1016/j.bjps.2009.06.024
发表时间：
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影响因子：
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作者：
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影响因子：
2.1
作者：
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通讯作者：
Volovici, Victor
影响因子：
0.5
作者：
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通讯作者：
Chong, Alphonsus K. S.
影响因子：
2.1
作者：
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通讯作者：
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