fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans.
fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans.
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DOI：
10.1093/genetics/119.1.43
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发表时间：
1988-05
期刊：
影响因子：
3.3
通讯作者：
T. Schedl;J. Kimble
中科院分区：
文献类型：
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作者：
T. Schedl;J. Kimble
本文描述了生殖系性别决定基因fog-2（fog为生殖系女性化）中16个突变的分离和表征。在秀丽隐杆线虫中，通常有两种性别，即自体雌雄同体（XX）和雄性（XO）。野生型XX动物在生殖细胞系中是雌雄同体的（精子发生后是卵子发生），而在索马中是雌性的。fog-2功能丧失突变将XX动物转变为雌性，而XO动物不受影响。因此，野生型fog-2是雌雄同体而非雄性精子发生所必需的。fem基因和fog-1基因对XX和XO动物的精子发生都是必不可少的。fog-2作为fem基因和fog-1的正调节因子。tra-2和tra-3基因充当fem基因和fog-1的负调节因子，以允许卵子发生。两个模型讨论了如何雾-2可能积极调节fem基因和雾-1，使精子发生;雾-2可能作为一个负调节tra-2和tra-3，或雾-2可能积极作用于fem基因和雾-1呈现不敏感的tra-2和tra-3的负面作用。
This paper describes the isolation and characterization of 16 mutations in the germ-line sex determination gene fog-2 (fog for feminization of the germ line). In the nematode Caenorhabditis elegans there are normally two sexes, self-fertilizing hermaphrodites (XX) and males (XO). Wild-type XX animals are hermaphrodite in the germ line (spermatogenesis followed by oogenesis), and female in the soma. fog-2 loss-of-function mutations transform XX animals into females while XO animals are unaffected. Thus, wild-type fog-2 is necessary for spermatogenesis in hermaphrodites but not males. The fem genes and fog-1 are each essential for specification of spermatogenesis in both XX and XO animals. fog-2 acts as a positive regulator of the fem genes and fog-1. The tra-2 and tra-3 genes act as negative regulators of the fem genes and fog-1 to allow oogenesis. Two models are discussed for how fog-2 might positively regulate the fem genes and fog-1 to permit spermatogenesis; fog-2 may act as a negative regulator of tra-2 and tra-3, or fog-2 may act positively on the fem genes and fog-1 rendering them insensitive to the negative action of tra-2 and tra-3.