A retrospective multicenter analysis of elderly Hodgkin lymphoma: outcomes and prognostic factors in the modern era
A retrospective multicenter analysis of elderly Hodgkin lymphoma: outcomes and prognostic factors in the modern era
复制标题
DOI：
10.1182/blood-2011-09-378414
复制
发表时间：
2012-01-19
期刊：
影响因子：
20.3
通讯作者：
Smith, Sonali M.
中科院分区：
文献类型：
--
作者：
Evens, Andrew M.;Helenowski, Irene;Smith, Sonali M.
调查了最近(1999年1月至2009年12月)95名老年霍奇金淋巴瘤患者的队列。确诊时，中位年龄为67岁(范围为60-89岁)，61%的患者有明显的合并症，26%的患者身体状况不佳，17%的患者有老年综合征，13%的患者丧失日常生活能力。治疗的总有效率为85%，而博莱霉素肺毒性的发生率为32%(相关死亡率为25%)。中位随访时间66个月，2年和5年总生存率分别为73%和58%(晚期分别为63%和46%)。大多数国际预后评分因素在单因素分析中不能预测预后，而COX多因素回归分析发现两个危险因素：(1)年龄>70岁(2.24；95%CI，1.16~4.33，P=0.02)和(2)日常生活能力丧失(2.71；95%CI，1.07~6.84，P=0.04)。此外，基于这些危险因素(0、1或2)的新生存模型显示，2年OS分别为83%、70%和13%(P<；.0001)，5年OS分别为73%、51%和0(P<；.0001)。(《血色》2012；119(3)：692-695)
investigated a recent (January 1999 to December 2009) cohort of 95 elderly Hodgkin lymphoma subjects. At diagnosis, median age was 67 years (range, 60-89 years), whereas 61% had significant comorbidity, 26% were unfit, 17% had a geriatric syndrome, and 13% had loss of activities of daily living. Overall response rate to therapy was 85%, whereas incidence of bleomycin lung toxicity was 32% (with associated mortality rate, 25%). With 66-month median follow-up, 2-year and 5-year overall survival were 73% and 58%, respectively (advanced-stage, 63% and 46%, respectively). Most International Prognostic Score factors were not prognostic on univariate analyses, whereas Cox multivariate regression identified 2 risk factors associated with inferior overall survival: (1) age more than 70 years (2.24; 95% CI, 1.16-4.33, P = .02) and (2) loss of activities of daily living (2.71; 95% CI, 1.07-6.84, P = .04). Furthermore, a novel survival model based on number of these risk factors (0, 1, or 2) showed differential 2-year OS of 83%, 70%, and 13%, respectively (P < .0001) and 5-year OS of 73%, 51%, and 0%, respectively (P < .0001). (Blood.2012;119(3):692-695)