Beneficial effect of body weight control on left ventricular diastolic function in the general population: an analysis of longitudinal data from a health check-up clinic
Beneficial effect of body weight control on left ventricular diastolic function in the general population: an analysis of longitudinal data from a health check-up clinic
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DOI：
10.1093/ehjci/jex219
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发表时间：
2018-02-01
影响因子：
6.2
通讯作者：
Komuro, Issei
中科院分区：
文献类型：
--
作者：
Lee, Seitetz C.;Daimon, Masao;Komuro, Issei
目的左心室舒张功能不全可导致心力衰竭。高体重指数（BMI）与左室舒张功能差相关。然而，在BMI和LV舒张功能的变化之间的纵向关系的知识是limited.Methods和结果我们回顾性地确定了165无症状的个人（年龄60 +/- 10岁，55%男性）与保存LV射血分数，谁进行了反复的健康检查（中位间隔：365天）在我们的医院2009年和2012年之间。采用线性混合效应模型对纵向数据进行分析，调整基线时的重要临床变量，以评价从一次访视到下一次访视BMI变化与LV舒张功能之间的相关性。基线特征为BMI 23 ± 3 kg/m2; E/E'比值9 ± 2; E'流速8 ± 2 cm/s;左心房（LA）容积指数26 ± 8 mL/m2。82例受试者基线时左室舒张功能不全。在多变量分析中，BMI的变化与左室舒张功能的变化相关。连续访视之间BMI降低一个单位对应于LA容积指数平均降低0.80 mL/m（2）（95%置信区间：0.38，1.23; P < 0.001），E/E'比值降低0.11 E'波速度增加0.11cm/s（0.18，0.031; P = 0.006）。结论BMI的变化与左室舒张功能有关。BMI的降低对应于LA容积指数的显着降低和E'速度的显着增加。
Aims Left ventricular (LV) diastolic dysfunction may lead to heart failure. A high body mass index (BMI) is associated with worse LV diastolic function. However, knowledge of the longitudinal relation between changes in BMI and LV diastolic function is limited.Methods and results We retrospectively identified 165 asymptomatic individuals (aged 60 +/- 10 years, 55% male) with preserved LV ejection fraction, who underwent repeated health check-ups (median interval: 365 days) at our hospital between 2009 and 2012. The longitudinal data were analysed using a linear mixed-effects model adjusted for important clinical variables at baseline to evaluate the associations between changes in BMI and LV diastolic function from one visit to the next. Baseline characteristics were BMI, 23 +/- 3 kg/m(2); E/E' ratio, 9 +/- 2; E' velocity, 8 +/- 2 cm/s; and left atrial (LA) volume index, 26 +/- 8 mL/m(2). Eighty-two of our participants had baseline LV diastolic dysfunction. In multivariable analyses, a BMI change was associated with a change in LV diastolic function. A one-unit decrease in BMI between consecutive visits corresponded to an average decrease in LA volume index of 0.80 mL/m(2) (95% confidence interval: 0.38, 1.23; P < 0.001), a decrease in E/E' ratio of 0.11 (-0.015, 0.23; P = 0.086), and an increase in E' velocity of 0.11 cm/s (0.18, 0.031; P = 0.006).Conclusion Our study showed that there was an association between changes in BMI and LV diastolic function. A decrease in BMI corresponded to a significant decrease in LA volume index and a significant increase in E' velocity.