Localization of Deep Brain Stimulation Electrode by Image Registration Is Software Dependent: A Comparative Study between Four Widely Used Software Programs
Localization of Deep Brain Stimulation Electrode by Image Registration Is Software Dependent: A Comparative Study between Four Widely Used Software Programs
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DOI：
10.1159/000494982
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发表时间：
2018-01-01
影响因子：
1.7
通讯作者：
Cuny, Emmanuel
中科院分区：
文献类型：
--
作者：
Engelhardt, Julien;Guehl, Dominique;Cuny, Emmanuel
背景资料：控制有源触点的解剖位置对于了解神经刺激的效果和调整神经刺激的设置至关重要。通常通过术前MRI和术后CT扫描之间的配准来评估定位。然而，其准确性取决于配准算法的质量，并且许多软件程序可用。目的：比较四种注册器械之间植入的脑深部电刺激（DBS）电极导线在丘脑底核（DBS）中的定位。研究方法：对27例因帕金森病（53根电极导线）植入颅内的患者进行术前立体定向MRI配准并与术后3个月CT扫描融合。在立体定向框架空间中计算活动触点的定位，并在软件程序之间进行比较。结果如下：3个轴的软件程序之间的活动触点坐标不同（p < 0.001），最深接触位置之间的平均向量误差为1.17 mm（95% CI 1.09-1.25）。结论：我们发现在四种不同设备上计算的坐标存在微小但显著的差异。在进行比较有效接触位置的研究或对植入DBS电极导线的患者进行随访时，必须考虑这些结果。(C)2018 S. Karger AG，巴塞尔
Background: The control of the anatomic position of the active contacts is essential to understand the effects and adapt the settings of the neurostimulation. The localization is commonly assessed by a registration between the preoperative MRI and the postoperative CT scan. However, its accuracy depends on the quality of the registration algorithm and many software programs are available. Objective: To compare the localization of implanted deep brain stimulation (DBS) leads in the subthalamic nucleus (STN) between four registration devices. Methods: The preoperative stereotactic MRI was co-registered and fused with the 3-month postoperative CT scan in 27 patients implanted in the STN for Parkinson's disease (53 leads). Localizations of the active contacts were calculated in the stereotactic frame space and compared between software programs. Results: The coordinates of the active contacts were different between software programs in the 3 axes (p < 0.001) with a mean vectorial error between the deepest contact locations of 1.17 mm (95% CI 1.09-1.25). Conclusion: We found a small but significant difference in the coordinates calculated on four different devices. These results have to be considered when performing studies comparing active contact locations or when following patients with an implanted DBS lead. (C) 2018 S. Karger AG, Basel