Visceral adipose tissue: relations between single-slice areas and total volume
Visceral adipose tissue: relations between single-slice areas and total volume
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DOI：
10.1093/ajcn/80.2.271
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发表时间：
2004-08-01
影响因子：
7.1
通讯作者：
Heshka, S
中科院分区：
文献类型：
--
作者：
Shen, W;Punyanitya, M;Heshka, S
背景资料：内脏脂肪组织（VAT）与肥胖的代谢后果有关，通常通过测量L4-L5椎间隙的VAT面积来表征。然而，切片的位置与最强的关系增值税volume.Objective：我们试图探讨横截面增值税领域在不同的解剖位置和增值税体积在一个大的，不同的健康受试者样本之间的关系。设计图：VAT体积来自于121名健康男性的磁共振图像中以5 cm间隔获取的切片面积[x SD年龄：41.9 ± 15.8岁;体重指数：（BMI;单位kg/m2）：26.0 +/- 3.2; VAT：2.7 +/- 1.8 L]和198名健康女性（年龄：48.1 +/- 18.7 y; BMI：27.0 +/- 5.4; VAT：1.7 +/- 1.2 Q）。结果：男性L4-L5上方10 cm（A（+10））的VAT面积（R-2 = 0.932，P < 0.001），女性L4-L5上方5 cm（A（+5））的VAT面积（R-2 = 0.945，P < 0.001）。P < 0.001）与腹部增值税相关性最高。调整年龄、种族、扫描位置、BMI和腰围后，男性R2仅增加3.8%，女性增加0.5%。研究中使用A（+10），在男性和A（+5）在女性将需要14%和9%的受试者少，分别比那些使用切片在L4-L5和将有同等的权力。结论：测量切片面积在A（+10）在男性和A（+5）在女性提供了更大的权力比测量在L4-L5的VAT体积差异的检测。
Background: Visceral adipose tissue (VAT), which is linked with the metabolic consequences of obesity, is usually characterized by measuring VAT area at the L4-L5 vertebral interspace. However, the location of the slice with the strongest relation to VAT volume is not established.Objective: We sought to investigate the relations between cross-sectional VAT areas at different anatomic locations and VAT volume in a large, diverse sample of healthy subjects. Design: VAT volume was derived from slice areas taken at 5-cm intervals from magnetic resonance images in 121 healthy men [x SD age: 41.9 +/- 15.8 y; body mass index (BMI; in kg/m(2)) : 26.0 +/- 3.2; VAT: 2.7 +/- 1.8 L] and 198 healthy women (age: 48.1 +/- 18.7 y; BMI: 27.0 +/- 5.4; VAT: 1.7 +/- 1.2 Q. Regression models were developed to identify the best single slice for estimating VAT volume.Results: The VAT area 10 cm above L4-L5 (A(+10)) in men (R-2 = 0.932, P < 0.001) and 5 cm above L4-L5 (A(+5)) in women (R-2 = 0.945. P < 0.001) had the highest correlation with abdominal VAT. R 2 increased by only 3.8% in men and 0.5% in women with adjustment for age, race, scanning position, BMI, and waist circumference. Studies using A(+10), in men and A(+5) in women will require 14% and 9% fewer subjects, respectively, than those using slices at L4-L5 and will have equivalent power.Conclusion: Measurement of slice areas at A(+10) in men and A(+5) in women provides greater power for the detection of VAT volume differences than does measurement at L4-L5.