Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients:: A proteomic study
Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients:: A proteomic study
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DOI：
10.1021/pr060600i
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发表时间：
2007-01-01
影响因子：
4.4
通讯作者：
Macaya, Carlos
中科院分区：
文献类型：
--
作者：
Lopez-Farre, Antonio J.;Mateos-Caceres, Petra J.;Macaya, Carlos
我们的目的是分析阿司匹林（乙酰水杨酸[阿萨]）敏感和ASA抵抗的冠状动脉缺血患者的血浆蛋白质组。分析了19例ASA敏感和19例ASA耐药患者的血浆。对于蛋白质组学研究，进行了双向电泳。ASA耐药患者中纤维蛋白原γ链的一种同种型和结合珠蛋白的三种同种型的表达增加。三种维生素D结合蛋白同种型在ASA耐药患者中增加。在体外培养的维生素D结合蛋白（DBP）与健康志愿者的血液降低了阿萨对血栓素A（2）产生的抑制作用。DBP可能是阿萨抑制血小板作用的一个新的调节因子。
Our aim was to analyze the plasma proteome in aspirin (acetylsalicylic acid [ASA])-sensitive and ASA-resistant coronary ischemic patients. Plasma from 19 ASA-sensitive and 19 ASA-resistant patients was analyzed. For the proteomic study, two-dimensional electrophoresis was performed. The expression of one isotype of the fibrinogen gamma chain and three isotypes of haptoglobin was increased in ASA-resistant patients. Three vitamin D binding protein isotypes were increased in ASA-resistant patients. In vitro incubation of vitamin D binding protein (DBP) with blood from healthy volunteers reduced the inhibitory effect of ASA on thromboxane A(2) production. DBP may be a new regulator of the inhibitory effect of ASA on platelets.