Increased interhemispheric resting-state functional connectivity after sleep deprivation: a resting-state fMRI study
Increased interhemispheric resting-state functional connectivity after sleep deprivation: a resting-state fMRI study
复制标题
睡眠剥夺后半球间静息态功能连接增加：静息态功能磁共振成像研究。
DOI：
10.1007/s11682-015-9490-5
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发表时间：
2016-09-01
影响因子：
3.2
通讯作者：
Qin, Wei
中科院分区：
文献类型：
--
作者：
Zhu, Yuanqiang;Feng, Zhiyan;Qin, Wei
一些功能成像研究已经调查了睡眠剥夺（SD）对受损脑功能的区域影响;然而，SD后大脑半球之间的功能相互作用的潜在变化尚不清楚。在这项研究中，我们使用了一个最近验证的方法，体素镜像同伦连接（VMHC），直接检查的变化，半球间的同伦静息态功能连接（RSFC）后SD。在28名参与者中进行了静息状态功能MRI（fMRI），无论是在休息清醒（RW）后还是在SD后。通过计算每种条件下每个受试者的每对同伦体素时间序列之间的Pearson相关性（Fisher Z变换）获得半球间RSFC图。然后分别在全局和体素水平上检查两半球间RSFC的条件差异。睡眠剥夺后，VMHC显著增加，具体而言，VMHC显著增加，发现在特定的大脑区域，包括丘脑，中央旁小叶，辅助运动区，中央后回和舌回。睡眠剥夺后VMHC无明显降低。进一步的分析表明，这些发现并不依赖于在预处理步骤中采用的各种大小的平滑核，并且在这些区域中的差异在有或没有全局信号回归的情况下仍然是显著的。我们的数据表明，增加VMHC可能反映了双侧脑区，特别是双侧丘脑的代偿性参与，以防止认知性能恶化时，睡眠剥夺后睡眠压力升高。我们的研究结果提供了初步的证据，纵裂相关性的变化后SD和有助于更好地了解SD的神经机制。
Several functional imaging studies have investigated the regional effects of sleep deprivation (SD) on impaired brain function; however, potential changes in the functional interactions between the cerebral hemispheres after SD are not well understood. In this study, we used a recently validated approach, voxel-mirrored homotopic connectivity (VMHC), to directly examine the changes in interhemispheric homotopic resting-state functional connectivity (RSFC) after SD. Resting-state functional MRI (fMRI) was performed in 28 participants both after rest wakefulness (RW) and a total night of SD. An interhemispheric RSFC map was obtained by calculating the Pearson correlation (Fisher Z transformed) between each pair of homotopic voxel time series for each subject in each condition. The between-condition differences in interhemispheric RSFC were then examined at global and voxelwise levels separately. Significantly increased global VMHC was found after sleep deprivation; specifically, a significant increase in VMHC was found in specific brain regions, including the thalamus, paracentral lobule, supplementary motor area, postcentral gyrus and lingual gyrus. No regions showed significantly reduced VMHC after sleep deprivation. Further analysis indicates that these findings did not depend on the various sizes of smoothing kernels that were adopted in the preprocessing steps and that the differences in these regions were still significant with or without global signal regression. Our data suggest that the increased VMHC might reflect the compensatory involvement of bilateral brain areas, especially the bilateral thalamus, to prevent cognitive performance deterioration when sleep pressure is elevated after sleep deprivation. Our findings provide preliminary evidence of interhemispheric correlation changes after SD and contribute to a better understanding of the neural mechanisms of SD.