Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
复制标题
DOI：
10.1586/eri.13.17
复制
发表时间：
2013-04-01
影响因子：
5.7
通讯作者：
Quindos, Guillermo
中科院分区：
文献类型：
--
作者：
Carrillo-Munoz, Alfonso Javier;Tur-Tur, Cristina;Quindos, Guillermo
舍他康唑是一种有效的抗真菌剂，可对抗皮肤和粘膜真菌病，例如皮肤、生殖器和口腔念珠菌病以及足癣。其抗真菌活性是由于麦角甾醇生物合成的抑制和细胞壁的破坏。在较高浓度下，舍他康唑能够与真菌细胞壁的非甾醇脂质结合，增加真菌细胞的通透性和随后的死亡。对念珠菌的抑菌和杀真菌活性呈剂量依赖性。舍他康唑的抗真菌谱包括皮肤真菌、念珠菌、隐球菌、马拉色菌以及曲霉、Scedosporium 和 Scopulariopsis。舍他康唑还对链球菌、葡萄球菌和原生动物（毛滴虫）具有抗菌活性。在针对外阴阴道念珠菌病患者的临床试验中，与其他外用唑类药物（如益康唑和克霉唑）相比，单剂舍他康唑在较短的时间内产生了更高的治愈率。舍他康唑具有抗炎作用，对于缓解不适症状非常有用
Sertaconazole is a useful antifungal agent against mycoses of the skin and mucosa, such as cutaneous, genital and oral candidiasis and tinea pedis. Its antifungal activity is due to inhibition of the ergosterol biosynthesis and disruption of the cell wall. At higher concentrations, sertaconazole is able to bind to nonsterol lipids of the fungal cell wall, increasing the permeability and the subsequent death of fungal cells. Fungistatic and fungicidal activities on Candida are dose-dependent. The antifungal spectrum of sertaconazole includes deramophytes, Candida, Cryptococcus, Malassezia and also Aspergillus, Scedosporium and Scopulariopsis. Sertaconazole also shows an antimicrobial activity against streptococci, staphylococci and protozoa (Trichomonas). In clinical trials including patients with vulvovaginal candidiasis, a single dose of sertaconazole produced a higher cure rate compared with other topical azoles such as econazole and clotrimazole, in shorter periods. Sertaconazole has shown an anti-inflammatory effect that is very useful for the relief of unpleasant symptoms