Telomere length reveals cumulative individual and transgenerational inbreeding effects in a passerine bird.
Telomere length reveals cumulative individual and transgenerational inbreeding effects in a passerine bird.
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端粒长度揭示了雀形目鸟类个体和跨代近亲繁殖的累积效应。
DOI：
10.1111/mec.13670
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发表时间：
2016-06
影响因子：
4.9
通讯作者：
Richardson DS
中科院分区：
文献类型：
--
作者：
Bebbington K;Spurgin LG;Fairfield EA;Dugdale HL;Komdeur J;Burke T;Richardson DS
近亲繁殖会产生更多的纯合后代，这些后代的适合度会降低，但由于几个原因，这些成本很难量化。首先，近亲繁殖抑制可能随生态或生理压力而变化，只有在很长一段时间内才能检测到。其次，亲本纯合性可能会间接影响后代的适合度，从而混淆仅考虑后代纯合性的分析。最后，对近交系数、存活率和繁殖成功率的测量往往过于粗糙，无法检测野生种群的近交成本。端粒长度为躯体成本提供了更精确的测量，预测了许多物种的生存，并反映了由于应对环境压力的能力不同而导致的躯体状况的差异。我们研究了塞舌尔莺（Acrocephalus sechellensis）野生种群的相对端粒长度，以评估反映该物种全基因组近亲繁殖的个体纯合性与端粒长度之间的终生关系。在幼鱼中，在淡季，个体纯合性与端粒长度呈负相关。在成人中，个体纯合性始终与端粒长度呈负相关，表明近交抑郁在一生中积累。母系纯合子对子代端粒长度也有负相关预测。我们的研究结果表明，体细胞近交成本在某些生命阶段依赖于环境，但可能在整个生命过程中积累。
Inbreeding results in more homozygous offspring that should suffer reduced fitness, but it can be difficult to quantify these costs for several reasons. First, inbreeding depression may vary with ecological or physiological stress and only be detectable over long time periods. Second, parental homozygosity may indirectly affect offspring fitness, thus confounding analyses that consider offspring homozygosity alone. Finally, measurement of inbreeding coefficients, survival and reproductive success may often be too crude to detect inbreeding costs in wild populations. Telomere length provides a more precise measure of somatic costs, predicts survival in many species and should reflect differences in somatic condition that result from varying ability to cope with environmental stressors. We studied relative telomere length in a wild population of Seychelles warblers (Acrocephalus sechellensis) to assess the lifelong relationship between individual homozygosity, which reflects genome‐wide inbreeding in this species, and telomere length. In juveniles, individual homozygosity was negatively associated with telomere length in poor seasons. In adults, individual homozygosity was consistently negatively related to telomere length, suggesting the accumulation of inbreeding depression during life. Maternal homozygosity also negatively predicted offspring telomere length. Our results show that somatic inbreeding costs are environmentally dependent at certain life stages but may accumulate throughout life.