Coronary dynamics and myocardial metabolism in the diabetic newborn lamb.
Coronary dynamics and myocardial metabolism in the diabetic newborn lamb.
复制标题
糖尿病新生羔羊的冠状动脉动力学和心肌代谢。
DOI：
--
复制
发表时间：
1979
影响因子：
--
通讯作者：
S. Downing
中科院分区：
文献类型：
--
作者：
J. Lee;S. Downing
通过单次静脉注射一水四氧嘧啶（150 mg/kg）， 17只新生羔羊发生糖尿病（DM）。24小时后，所有患者均出现高血糖（大于300 mg/100 ml）和糖尿，但无一人出现酮症尿或酸中毒。血浆胰岛素水平降低到血糖水平的20%左右。葡萄糖耐量试验（静脉注射）也与胰岛素储备减少一致。在恒定的血流动力学条件下，测量了16例糖尿病患者的左心室性能，与10例正常羔羊的左心室性能没有差异。然而，心肌对葡萄糖的摄取急剧减少，脂肪酸的摄取减少。心肌耗氧量（MVO2）不变。糖尿病患者冠状动脉血流（CF）明显降低（P < 0.001）。压力-流量研究也证实，与对照组相比，在给定的主动脉压下，糖尿病患者CF持续降低。这些结果表明，糖尿病羔羊的冠状动脉血管阻力升高，这不能用MVO2的变化来解释。增加提取量可以满足糖尿病心脏的需氧量。
Diabetes mellitus (DM) was produced in 17 neonatal lambs by a single intravenous injection of alloxan monohydrate (150 mg/kg). All developed hyperglycemia (greater than 300 mg/100 ml) and glycosuria after 24 h, but none exhibited ketonuria or acidosis. Plasma insulin levels were reduced to about 20% of those appropriate for the plasma glucose levels. Glucose tolerance tests (intravenous) were also consistent with reduced insulin reserve. Measurements of left ventricular performance were obtained under constant hemodynamic conditions in 16 diabetics and did not differ from those in 10 normal lambs. However, myocardial uptake of glucose was sharply reduced and fatty acid uptake was less. Myocardial O2 consumption (MVO2) was unchanged. Coronary flow (CF) was significantly lower in the diabetics (P less than 0.001). Pressure-flow studies were also done and demonstrated a consistent reduction in CF at a given aortic pressure in DM compared with controls. These findings indicate that coronary vascular resistance is elevated in the lamb with DM, and this is not explained by a change in MVO2. Oxygen requirements of the diabetic hearts were satisfied by increased extraction.