Modulation of horizontal cell function by dopaminergic ligands in mammalian retina.
Modulation of horizontal cell function by dopaminergic ligands in mammalian retina.
复制标题
哺乳动物视网膜中多巴胺能配体对水平细胞功能的调节。
DOI：
10.1016/j.visres.2008.03.004
复制
发表时间：
2008
期刊：
影响因子：
1.8
通讯作者：
Reitsamer,Herbert
中科院分区：
文献类型：
--
作者：
Pflug,Renate;Nelson,Ralph;Huber,Sonja;Reitsamer,Herbert
Light responses of rabbit horizontal cell somata (HC) to flickering light stimuli recorded with sharp electrodes consist of a distinctive flicker component superimposed on a sustained hyperpolarisation. Activation of dopamine D1/D5 receptors depolarises HC dark membrane potential and suppresses the flicker component of responses to photopic stimuli without affecting the sustained hyperpolarising response component. Waveforms of responses to scotopic stimuli are preserved. Similar response modulation was observed in depolarising cells of the inner retina, suggesting that activation of D1/D5 receptors of HC causes modification of cone signal transmission to higher order neurons. The impact of dopamine D1/D5 receptor activation on the function of HC in the light stimulated retina is discussed.
