Age-related changes in cell-mediated immunity in BALB/C mice.
Age-related changes in cell-mediated immunity in BALB/C mice.
复制标题
BALB/C 小鼠细胞介导免疫的年龄相关变化。
作者：
C. Walters;H. Claman
在BALB/c小鼠中，用四种不同的测定系统在体外和体内研究了年龄增加对细胞介导的免疫的各种测试的影响。获得了以下结果。1)在对DNFB的接触敏感性方面，老年小鼠（年龄60至80周）与年轻成年小鼠（年龄8至12周）相比，在致敏性方面没有差异。(In相反，与年轻的NZB/W小鼠相比，老年NZB/W小鼠显示出受损的接触致敏性。2)与接触敏感性反应不同，来自老年BALB/c小鼠的细胞在引发移植物抗宿主反应方面存在缺陷。当转移部分纯化的T细胞群时也是如此。3)在混合淋巴细胞反应中，来自老年小鼠的细胞在响应或刺激同种异体细胞方面与来自年轻成年BALB/c小鼠的细胞一样有效或更好。4)与来自年轻成年小鼠的细胞相比，当培养老年细胞时，对PHA和Con A（两者都是T细胞有丝分裂原）的反应大大降低。因此，我们发现，在同一批小鼠中，年龄的增加与细胞介导的免疫功能的某些指标的能力增加和其他指标的能力降低有关。
The effect of increasing age on various tests of cell-mediated immunity was investigated in BALB/c mice both in vitro and in vivo with four different assay systems. The following results were obtained. 1) In contact sensitivity to DNFB, old mice (age 60 to 80 weeks) showed no differences in sensitization when compared to young adult mice (age 8 to 12 weeks). (In contrast, old NZB/W mice showed impaired contact sensitization when compared with young NZB/W MICE.)2) Unlike the reaction in contact sensitivity, cells from old BALB/c mice were defective in eliciting a graft-vs-host reaction. This was true also when a partially purified population of T cells was transferred. 3) In the mixed lymphocyte reaction, cells from old mice were as efficient or better than cells from young adult BALB/c mice in responding to or stimulating allogeneic cells. 4) Responses to PHA and Con A (Both T cell mitogens) were greatly reduced when old cells were cultured as compared with cells from young adult mice. Thus, we have found that within the same batch of mice, increasing age was associated with increased capabilities in some measures of cell-mediated immunologic function and decreased capabilities in other measures of the same.