ACUTE ALCOHOL ADMINISTRATION TO MICE INDUCES HEPATIC SINUSOIDAL ENDOTHELIAL-CELL DYSFUNCTION
ACUTE ALCOHOL ADMINISTRATION TO MICE INDUCES HEPATIC SINUSOIDAL ENDOTHELIAL-CELL DYSFUNCTION
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DOI：
10.1016/0928-4346(94)90016-7
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发表时间：
1994-02-15
期刊：
影响因子：
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通讯作者：
DSOUZA, NB
中科院分区：
文献类型：
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作者：
DEACIUC, IV;SPITZER, JJ;DSOUZA, NB
给小鼠乙醇（4.4 g kg（-1）体重量，i.p.）诱导血浆透明质酸（HA）浓度显著增加（125%），同时分离的灌注肝脏对HA的摄取显著减少（46%）。在静脉注射大肠杆菌脂多糖（1 mg kg（-1）体重量）后，也出现了类似的变化，这是一种库普弗细胞的强活化剂。由于：(a)肝脏HA摄取主要是窦内皮细胞的功能，反映了它们的功能状态；(b)肝脏是血液中HA清除的主要部位，我们得出结论，酒精改变了窦内皮细胞的功能，包括HA的内吞作用。库普弗细胞功能状态的改变可能是乙醇和LPS对窦状内皮细胞影响的主要原因。
Ethanol administration to mice (4.4 g kg(-1) body wt., i.p.) induced a marked increase (125%) in plasma hyaluronan (HA) concentration associated with a significant decrease (46%) in HA uptake by the isolated, perfused liver. Similar changes were obtained after i.v. administration of Escherichia coli lipopolysaccaharide (1 mg kg(-1) body wt.), a strong activator of Kupffer cells. Since: (a) hepatic HA uptake is predominantly a function of the sinusoidal endothelial cells, reflecting their functional stale, and (b) liver is a major site of HA clearance from the blood, we conclude that alcohol alters sinusoidal endothelial cell functions, including HA endocytosis. Changes in Kupffer cell functional state may be a primary event underlying the effects of both ethanol and LPS on sinusoidal endothelial cells.