A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.
A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.
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DOI：
10.1021/ol702846t
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发表时间：
2008-01
期刊：
影响因子：
5.2
通讯作者：
Dexuan Xiang;Kewei Wang;Yongjiu Liang;Guang-Pei Zhou;D. Dong
中科院分区：
文献类型：
--
作者：
Dexuan Xiang;Kewei Wang;Yongjiu Liang;Guang-Pei Zhou;D. Dong
A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.
