Polyunsaturated Fatty Acid Levels of Serum and Red Blood Cells in Apparently Healthy Japanese Subjects Living in an Urban Area
Polyunsaturated Fatty Acid Levels of Serum and Red Blood Cells in Apparently Healthy Japanese Subjects Living in an Urban Area
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DOI：
10.5551/jat.2618
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发表时间：
2010-01-01
影响因子：
4.4
通讯作者：
Daida, Hiroyuki
中科院分区：
文献类型：
--
作者：
Yanagisawa, Naotake;Shimada, Kazunori;Daida, Hiroyuki
目的：我们评估水平的多不饱和脂肪酸（PUFA）在血清和红细胞（RBC）分层的世代和其临床意义在日本科目生活在一个城市area.Methods：我们招募了200名健康的日本人（126名男性，平均年龄：50.3 +/- 9.2岁）生活在城市地区。测定每代血清和红细胞中PUFA的水平，包括二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）、花生四烯酸（AA）和二高-γ-亚麻酸（DGLA结果：EPA、DHA、AA、EPA/AA在男女间无显著性差异。在分成几代后，在血清中观察到EPA和DHA的逐步增加，但DGLA或AA没有（所有p < 0.0001）。EPA/AA比率在血清（平均值：G1：0.26，G2：0.29，G3：0.43，G4：0.58，G5：0.68，p < 0.0001）和RBC（平均值：G1：0.10，G2：0.09，G3：0.15，G4：0.20，G5：0.23，p < 0.0001）中逐步增加。血清与红细胞EPA、DHA、DGLA、AA、EPA/AA呈正相关（r = 0.83、r = 0.55、r = 0.54、r = 0.29、r = 0.91）。此外，EPA/AA的比率和胰岛素敏感性之间的显着正相关，以及这些比率和胰岛素抵抗之间的负相关性，观察代谢syndrome.Conclusion：低水平的EPA/AA，这是与胰岛素抵抗，表现在日本年轻的成年人生活在城市地区。
Aim: We assessed levels of polyunsaturated fatty acid (PUFA) in serum and red blood cells (RBCs) among groups stratified by generation and its clinical significance in Japanese subjects living in an urban area.Methods: We enrolled 200 apparently healthy Japanese (126 males, mean age:50.3 +/- 9.2 years) living in an urban area. Levels of PUFA, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-gamma-linolenic acid (DGLA) in serum and RBCs were measured for each generation (G1 < 35y, G2 35y - < 45y, G3 45y - < 55y, G4 55y - < 65y, G5 >= 65y).Results: No significant differences in EPA, DHA, AA, or EPA/AA were observed between males and females. After dividing into generations, stepwise increases in EPA and DHA, but not DGLA or AA, were observed in serum (all p < 0.0001). EPA/AA ratios were stepwisely increased in serum (mean: G1:0.26, G2:0.29, G3:0.43, G4:0.58, G5:0.68, p < 0.0001) and RBCs (mean:G1:0.10, G2:0.09, G3:0.15, G4:0.20, G5:0.23, p < 0.0001). Positive correlations of EPA (r = 0.83), DHA (r = 0.55), DGLA (r = 0.54), AA (r = 0.29), and EPA/AA (r = 0.91) were demonstrated between serum and RBCs. In addition, a significant positive correlation between EPA/AA ratios and insulin sensitivity as well as a negative correlation between those ratios and insulin resistance were observed in subjects with metabolic syndrome.Conclusion: Low levels of EPA/AA, which were associated with insulin resistance, were demonstrated in young Japanese adults living in an urban area.