Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilepsy center
Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilepsy center
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DOI：
10.1016/j.seizure.2004.01.009
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发表时间：
2004-12-01
影响因子：
3
通讯作者：
Morris, GL
中科院分区：
文献类型：
--
作者：
Spanaki, MV;Allen, LS;Morris, GL
目的：本回顾性研究记录了接受迷走神经刺激（VNS）治疗耐药癫痫患者的长期疗效。方法：回顾28例植入5年及以上患者的病历，观察VNS治疗1年及随访5 ~ 7年期间癫痫发作频率的变化。计算患者1年及随访时服用抗癫痫药物（aed）的数量。一名患者死亡，一名患者停止了VNS治疗；有26例患者的数据。结果：癫痫发作频率较基线变化的中位数百分比从12个月时的-28% （P = 0.0053， Wilcoxon sign -rank检验）增加到随访时的-72% （P < 0.0001）。一些患者在最初的12个月VNS治疗期间癫痫发作频率没有降低，但在随访期间癫痫发作频率有所降低。结论：在这项回顾性研究中，VNS治疗的有效性随着时间的推移而增加。医生应该意识到，一些患者对VNS治疗的反应可能会延迟。(C) 2004东亚贸易有限公司Elsevier Ltd.出版。版权所有。
Objective: This retrospective study documented long-term outcome of patients receiving vagus nerve stimulation (VNS) therapy for pharmacoresistant epilepsy. Methods: Medical charts of 28 patients implanted for 5 years or longer were reviewed for changes in seizure frequency after 1 year of VNS therapy and at follow up, which ranged from 5 to 7 years. Numbers of antiepileptic drugs (AEDs) taken by the patients were also computed at 1 year and follow up. One patient had died and one had discontinued VNS therapy; data were available for 26 patients. Results: The median percent change in seizure frequency from baseline increased from -28% (P = 0.0053, Wilcoxon signed-rank test) at 12 months to -72% (P < 0.0001) at follow up. Some patients whose seizure frequency was not reduced during the initial 12 months of VNS therapy did experience reductions in seizure frequency during the follow-up period. Conclusion: In this retrospective study, the effectiveness of VNS therapy increased over time. Physicians should be aware that response to VNS therapy may be delayed for some patients. (C) 2004 BEA Trading Ltd. Published by Elsevier Ltd. All rights reserved.