Estrogen and progesterone receptors in melanocytic lesions. Occurrence in patients with dysplastic nevus syndrome.
Estrogen and progesterone receptors in melanocytic lesions. Occurrence in patients with dysplastic nevus syndrome.
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黑素细胞病变中的雌激素和孕激素受体。
DOI：
10.1001/archderm.1985.01660100062015
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发表时间：
1985
影响因子：
--
通讯作者：
H. Solomon
中科院分区：
文献类型：
--
作者：
D. Ellis;R. Wheeland;H. Solomon
采用荧光雌激素和孕激素结合技术，对14例发育不良痣综合征患者的22个黑素细胞病变进行了雌激素和孕激素结合研究。这些患者的黑素细胞病变，包括原发性皮肤黑色素瘤，发育不良痣和良性痣，含有大量的雌激素和孕激素结合细胞。与一系列对照皮内痣进行比较，这些皮内痣几乎没有或没有可检测到的雌激素或孕激素结合。在黑色素瘤、黑色素瘤前体病变（如发育不良痣和先天性痣）以及发育不良痣综合征患者的良性痣中可以看到激素结合和可能的反应性增加。
Estrogen and progesterone binding studies in a series of 22 melanocytic lesions from 14 patients with the dysplastic nevus syndrome were done using a fluorescent estrogen and progesterone binding technique. Melanocytic lesions from these patients, including primary cutaneous melanomas, dysplastic nevi, and benign nevi, contained large numbers of estrogen and progesterone binding cells. Comparison is made to a series of control intradermal nevi that had little or no detectable estrogen or progesterone binding. Increased hormonal binding, and possibly responsiveness, is seen in melanomas, melanoma precursor lesions such as dysplastic nevi and congenital nevi, as well as benign nevi from patients with the dysplastic nevus syndrome.