Anticancer and Anti-Inflammatory Activity of Probiotic Lactococcus lactis NK34
Anticancer and Anti-Inflammatory Activity of Probiotic Lactococcus lactis NK34
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DOI：
10.4014/jmb.1503.03033
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发表时间：
2015-10-01
影响因子：
2.8
通讯作者：
Paik, Hyun-Dong
中科院分区：
文献类型：
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作者：
Han, Kyoung Jun;Lee, Na-Kyoung;Paik, Hyun-Dong
证明了益生菌乳球菌NK34的抗癌和抗炎活性。乳酸乳杆菌NK34 10(6)cfu/孔对SK-MES-1、DLD-1、HT-29、LoVo、AGS和MCF-7等癌细胞的增殖有明显的抑制作用(细胞毒性77%，p<；0.05)。乳酸乳杆菌NK34在脂多糖诱导的RAW 264.7细胞中也显示出抗炎活性，其中一氧化氮和促炎细胞因子(肿瘤坏死因子-α、白介素18和环氧合酶-2)的产生减少。这些结果表明，乳酸乳杆菌NK34可以作为一种益生菌来抑制癌细胞的增殖和促炎细胞因子的产生。
The anticancer and anti-inflammatory activities of probiotic Lactococcus lactis NK34 were demonstrated. Treatment of cancer cells such as SK-MES-1, DLD-1, HT-29, LoVo, AGS, and MCF-7 cells with 10(6) CFU/well of L. lactis NK34 resulted in strong inhibition of proliferation (>77% cytotoxicity, p < 0.05). The anti-inflammatory activity of L. lactis NK34 was also demonstrated in lipopolysaccharide-induced RAW 264.7 cells, where the production of nitric oxide and proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-18, and cyclooxygenase-2) was reduced. These results suggest that L. lactis NK34 could be used as a probiotic microorganism to inhibit the proliferation of cancer cells and production of proinflammatory cytokines.