Construction of the adamantane core of plukenetione-type polycyclic polyprenylated acylphloroglucinols.
Construction of the adamantane core of plukenetione-type polycyclic polyprenylated acylphloroglucinols.
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DOI：
10.1021/jo801595y
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发表时间：
2008-11
期刊：
影响因子：
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通讯作者：
Ryukichi Takagi;Y. Inoue;K. Ohkata
中科院分区：
文献类型：
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作者：
Ryukichi Takagi;Y. Inoue;K. Ohkata
描述了 plukenetione 型多环聚异戊二烯化酰基间苯三酚 (PPAP) 的高度功能化金刚烷核心的构建。该方法的特点是通过连续的 Michael 反应构建双环[3.3.1]壬烷核心 (3)，并通过双环[3.3.1]壬烷前体 (2) 的酸催化环化构建 plukenetione 型 PPAP 的金刚烷核心。
The construction of a highly functionalized adamantane core of plukenetione-type polycyclic polyprenylated acylphloroglucinols (PPAPs) is described. The method features the construction of the bicyclo[3.3.1]nonane core (3) by successive Michael reactions and the construction of the adamantane core of plukenetione-type PPAPs by acid-catalyzed cyclization of a bicyclo[3.3.1]nonane precursor (2).