Cooperative Raman Spectroscopy for Real-Time In Vivo Nano-Biosensing
Cooperative Raman Spectroscopy for Real-Time In Vivo Nano-Biosensing
复制标题
用于实时体内纳米生物传感的协作拉曼光谱
DOI：
10.1109/tnb.2017.2749183
复制
发表时间：
2017
影响因子：
3.9
通讯作者：
Sun, Zhi
中科院分区：
文献类型：
--
作者：
Guo, Hongzhi;Jornet, Josep Miquel;Gan, Qiaoqiang;Sun, Zhi
在过去的几十年里，能够在纳米尺度上检测和测量不同现象的微型生物传感器的发展导致了疾病诊断和治疗技术的变革。其中，具有生物功能的拉曼纳米颗粒已被用于体外和体内多种生物制剂的诊断和检测。然而，现有的解决方案需要使用体积庞大的激光器来激发纳米粒子，以及同样体积庞大且昂贵的光谱仪来测量散射的拉曼信号，这限制了这种纳米生物传感技术的实用性和应用。此外，由于体内环境的高路径损耗，接收到的信号通常非常微弱，这阻碍了测量的准确性。本文首次提出了协作拉曼光谱重建用于实时体内纳米生物传感的概念。其基本思想是将单一的激发点和测量点（即激光器和光谱仪）替换为一个相互连接的纳米设备网络，该网络可以同时激发和测量纳米生物传感粒子。更具体地说，在提出的系统中，大量的纳米传感器共同和分布地收集纳米生物功能纳米颗粒（nbp）通过血管的拉曼响应。本文对该传感系统进行了详细的描述，并利用准确的光信号在体内传播模型和低复杂度的估计算法，证明了该传感系统的可行性。数值结果表明，在一定NBPs密度下，重构的拉曼光谱可以被恢复，并用于准确提取目标体内信息。
In the last few decades, the development of miniature biological sensors that can detect and measure different phenomena at the nanoscale has led to transformative disease diagnosis and treatment techniques. Among others, biofunctional Raman nanoparticles have been utilized in vitro and in vivo for multiplexed diagnosis and detection of different biological agents. However, existing solutions require the use of bulky lasers to excite the nanoparticles and similarly bulky and expensive spectrometers to measure the scattered Raman signals, which limit the practicality and applications of this nano-biosensing technique. In addition, due to the high path loss of the intra-body environment, the received signals are usually very weak, which hampers the accuracy of the measurements. In this paper, the concept of cooperative Raman spectrum reconstruction for real-time in vivo nano-biosensing is presented for the first time. The fundamental idea is to replace the single excitation and measurement points (i.e., the laser and the spectrometer, respectively) by a network of interconnected nano-devices that can simultaneously excite and measure nano-biosensing particles. More specifically, in the proposed system, a large number of nanosensors jointly and distributively collect the Raman response of nano-biofunctional nanoparticles (NBPs) travelling through the blood vessels. This paper presents a detailed description of the sensing system and, more importantly, proves its feasibility, by utilizing the accurate models of optical signal propagation in intra-body environment and low-complexity estimation algorithms. The numerical results show that with a certain density of NBPs, the reconstructed Raman spectrum can be recovered and utilized to accurately extract the targeting intra-body information.
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DOI：
10.1109/jsac.2003.816618
发表时间：
2003-10
期刊：
IEEE J. Sel. Areas Commun.
影响因子：
--
作者：
S. M. Haas;J. Shapiro
通讯作者：
S. M. Haas;J. Shapiro
影响因子：
6.1
作者：
WANG, LH;JACQUES, SL;ZHENG, LQ
通讯作者：
ZHENG, LQ
影响因子：
3.9
作者：
Guo, Hongzhi;Johari, Pedram;Sun, Zhi
通讯作者：
Sun, Zhi
影响因子：
--
作者：
J. C. Erdmann;R. Gellert
通讯作者：
R. Gellert
用于纳米网络无线光通信的金属等离子体纳米天线的建模和性能分析
影响因子：
3.9
作者：
Nafari, Mona;Jornet, Josep Miquel
通讯作者：
Jornet, Josep Miquel