Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin.

Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin.
复制标题

无症状单纯疱疹病毒 2 感染对包皮 T 细胞表型和功能的影响。

DOI：
10.1097/qad.0b013e328354675c
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发表时间：
2012
期刊：
AIDS (London, England)
影响因子：
--
通讯作者：
RakaiGenitalImmunologyResearchGroup
RakaiGenitalImmunologyResearchGroup
中科院分区：
--
文献类型：
--
作者：
Prodger,JessicaL;Gray,Ronald;Kigozi,Godfrey;Nalugoda,Fred;Galiwango,Ronald;Nehemiah,Kighoma;Kakanga,Moses;Hirbod,Taha;Wawer,MariaJ;Sewankambo,Nelson;Serwadda,David;Kaul,Rupert;RakaiGenitalImmunologyResearchGroup

文献摘要

相似文献

单纯疱疹病毒2型（HSV-2）增加了男性感染HIV的风险，并增加了包皮中的总体CD 4 + T细胞密度。使用常规男性包皮环切术中获得的组织，我们研究了HSV-2对乌干达男性包皮T细胞功能和表型的影响。HSV-2感染主要与包皮CD 4 + T细胞CCR 5表达的间隔化增加相关，这可能有助于HIV易感性。
Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4+ T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4+ T cells, which may contribute to HIV susceptibility.