Aerosol Susceptibility of Influenza Virus to UV-C Light
Aerosol Susceptibility of Influenza Virus to UV-C Light
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DOI：
10.1128/aem.06960-11
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发表时间：
2012-03-01
影响因子：
4.4
通讯作者：
Radonovich, Lewis J.
中科院分区：
文献类型：
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作者：
McDevitt, James J.;Rudnick, Stephen N.;Radonovich, Lewis J.
由于广泛的死亡率和发病率，流感病毒在人与人之间的传播，特别是在由H5N1禽流感等高毒力流感毒株引起的大流行中，令人极为关切。季节性流感的后果也很严重。由于空气传播似乎在流感传播中发挥了作用，公共卫生干预措施应侧重于预防或阻断这一过程。在公共建筑中，通过上层房间254纳米杀菌紫外线(UV-C)灯进行空气消毒，可能能够减少通过空气传播的流感传播。我们利用配备了紫外线照射窗的台式小室研究了甲型H1N1流感病毒(H1N1，PR-8)气溶胶对UV-C光的敏感性。我们评估了病毒在三个相对湿度水平(25、50和75%)下对UV-C剂量从4到12 J/m(2)的敏感性。我们的数据显示，Z值(敏感因子)比以前报道的更高(更敏感)UV-C。此外，剂量-反应图显示，流感病毒的易感性随着相对湿度的降低而增加。这项工作为设计和利用有效的高层UV-C灯装置，通过表征其对UV-C的敏感性来预防流感的空气传播提供了必要的科学依据。
The person-to-person transmission of influenza virus, especially in the event of a pandemic caused by a highly virulent strain of influenza, such as H5N1 avian influenza, is of great concern due to widespread mortality and morbidity. The consequences of seasonal influenza are also substantial. Because airborne transmission appears to play a role in the spread of influenza, public health interventions should focus on preventing or interrupting this process. Air disinfection via upper-room 254-nm germicidal UV (UV-C) light in public buildings may be able to reduce influenza transmission via the airborne route. We characterized the susceptibility of influenza A virus (H1N1, PR-8) aerosols to UV-C light using a benchtop chamber equipped with a UVC exposure window. We evaluated virus susceptibility to UV-C doses ranging from 4 to 12 J/m(2) at three relative humidity levels (25, 50, and 75%). Our data show that the Z values (susceptibility factors) were higher (more susceptible) to UV-C than what has been reported previously. Furthermore, dose-response plots showed that influenza virus susceptibility increases with decreasing relative humidity. This work provides an essential scientific basis for designing and utilizing effective upper-room UV-C light installations for the prevention of the airborne transmission of influenza by characterizing its susceptibility to UV-C.