Smoking during pregnancy increases the risk of preterm births among parous women
Smoking during pregnancy increases the risk of preterm births among parous women
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DOI：
10.1034/j.1600-0412.2000.079008644.x
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发表时间：
2000-08-01
影响因子：
4.3
通讯作者：
Salvesen, KÅ
中科院分区：
文献类型：
--
作者：
Kolås, T;Nakling, J;Salvesen, KÅ
背景我们想研究怀孕期间吸烟与早产之间的可能联系。一项基于人群的前瞻性研究在一家分娩诊所连续7年分娩的7.236例孕妇中进行。吸烟习惯是在孕18周左右的常规超声检查中获得的，早产定义为在孕24至37周之间分娩。我们使用多元逻辑回归分析来估计吸烟、可能的混杂变量和早产之间的相对风险（比值比）。总体而言，1，769名（25%）妇女表示她们在怀孕期间每天吸烟。与不吸烟者相比，吸烟妇女早产的风险增加（比值比1.53，95%置信区间1.24，1.89）。然而，这种关联仅在经产妇女中得到证实（比值比1.88。95%置信区间为1.39。2.54）。在多变量分析中，调整母亲年龄、糖尿病、宫颈锥切术、先兆子痫、胎盘早剥和前置胎盘后，该相关性具有统计学意义，我们观察到母亲吸烟对多产妇女早产的剂量反应效应。对于经产妇女来说，怀孕期间吸烟会增加早产的风险，并且似乎存在吸烟的剂量反应效应。
Background. We wanted to study a possible association between smoking during pregnancy and preterm birth.Methods. A population based prospective study was performed among 7.236 consecutive pregnancies over seven years delivered at one birth clinic. Smoking habits were obtained at a routine ultrasound examination around 18 gestational weeks, and preterm birth was defined as delivery of a child between 24 and 37 gestational weeks. We estimated relative risk (odds ratio) between smoking, possible confounding variables and preterm birth using multiple logistic regression analysis.Results. Overall, 1,769 (25%) women said that they smoked every day during their pregnancy. The smoking women had an increased risk of preterm delivery compared with non-smokers (odds ratio 1.53, 95% confidence interval 1.24, 1.89). However, this association was only demonstrated among the multiparous women (odds ratio 1.88. 95% confidence interval 1.39. 2.54). The association was statistically significant after adjusting for maternal age, diabetes, cervical conization, preeclampsia, placental abruption and placenta previa in a multivariate analysis, and we observed a dose-response effect of maternal smoking on preterm birth among multiparous women.Conclusion. For multiparous women smoking during pregnancy increases the risk of preterm delivery, and there seems to be a dose-response effect of smoking.