Effect of acute sleep deprivation on heart rate recovery in healthy young adults
Effect of acute sleep deprivation on heart rate recovery in healthy young adults
复制标题
急性睡眠不足对健康年轻人心率恢复的影响
DOI：
10.1007/s11325-014-1066-x
复制
发表时间：
2015-05-01
影响因子：
2.5
通讯作者：
Basaran, Yelda
中科院分区：
文献类型：
--
作者：
Cincin, Altug;Sari, Ibrahim;Basaran, Yelda
睡眠剥夺（SD）与心血管不良事件发生率增加有关，但其潜在的病理生理机制尚未得到明确证实。自主神经系统在心血管功能的调节中起着重要作用，该系统的损害与心血管疾病死亡率的增加有关。本研究的目的是通过测定心率恢复（HRR）来研究急性SD对心功能自主调节的影响。健康保安员21名，护士9名，平均年龄33.25±8.18岁。跑步机运动试验分别在正常睡眠后和在医院夜班后进行。HRR计算为从运动峰值到第30秒（HRR30）、第1分钟（HRR1）、第2分钟（HRR2）、第3分钟（HRR3）和第5分钟（HRR5）的心率降低。同时测定血压（BP）的变化。SD个体的运动能力显著降低（10.96 +/- 1.01 vs. 11.71 +/- 1.30代谢当量任务s）；p = 0.002)，峰值收缩压明显升高（173.8 +/- 16.3 vs. 166.2 +/- 9.9; p = 0.019）。HRR30 （12.74 +/- 6.19 vs. 17.66 +/- 5.46, p = 0.003）和HRR1 （31 +/- 6.49 vs. 36.10 +/- 7.78, p = 0.004）差异有统计学意义。这些指标与峰值HR的比值也显著降低，SD (HRR%(30) 8.04 +/- 4.26 vs. 10.19 +/- 3.21；p = 0.025和嗯%(1):18.66 + / - 4.43和20.98 + / - 4.72;P = 0.013)。其他HRR指标间差异无统计学意义。我们的研究结果表明，SD会减弱心血管自主反应，这种关系的后果可能在经常失眠的受试者或基线心血管疾病的受试者中更为明显。
Sleep deprivation (SD) is known to be associated with increased incidence of adverse cardiovascular events, but underlying pathophysiological mechanism has not been clearly demonstrated. Autonomic nervous system plays an important role in the regulation of cardiovascular function, and impairment in this system is associated with increased cardiovascular mortality. The aim of the current study was to investigate the effect of acute SD on autonomic regulation of cardiac function by determining heart rate recovery (HRR).Twenty-one healthy security officers and nine nurses (mean age 33.25 +/- 8.18) were evaluated. Treadmill exercise test was applied once after a night with regular sleep and once after a night shift in hospital. The HRR was calculated as the reduction in heart rate from peak exercise to the 30th second (HRR30), 1st minute (HRR1), 2nd minute (HRR2), 3rd minute (HRR3), and 5th minute (HRR5). The change in blood pressure (BP) measurements was also determined.Exercise capacity of individuals with SD was significantly lower (10.96 +/- 1.01 vs. 11.71 +/- 1.30 metabolic equivalent task (MET)s; p = 0.002), and peak systolic BP was significantly higher (173.8 +/- 16.3 vs. 166.2 +/- 9.9; p = 0.019). There was a signicant difference in HRR30 (12.74 +/- 6.19 vs. 17.66 +/- 5.46; p = 0.003) and HRR1 (31 +/- 6.49 vs. 36.10 +/- 7.78; p = 0.004). The ratio of these indices to peak HR was also significantly lower with SD (HRR%(30) 8.04 +/- 4.26 vs. 10.19 +/- 3.21; p = 0.025 and HRR%(1): 18.66 +/- 4.43 vs. 20.98 +/- 4.72; p = 0.013). The difference in other indices of HRR was not significant.Our findings suggest that SD blunts cardiovascular autonomic response, and consequences of this relation might be more pronounced in subjects who are exposed to sleeplessness regularly or in subjects with baseline cardiovascular disease.