Non-24-hour sleep-wake syndrome following a car accident
Non-24-hour sleep-wake syndrome following a car accident
复制标题
DOI：
10.1212/01.wnl.0000061482.24750.7c
复制
发表时间：
2003-06-10
期刊：
影响因子：
9.9
通讯作者：
Chalk, C
中科院分区：
文献类型：
--
作者：
Boivin, DB;James, FO;Chalk, C
作者报告了一名39岁的视力正常的女性，她在车祸后出现了非24小时的睡眠-觉醒周期。血浆褪黑激素和6-硫酸氧褪黑激素节律等内源性昼夜节律标志物与自我选择的睡眠时间之间的相位关系异常。一项实验室调查表明，她对作为昼夜节律同步器的强光敏感。MRI和脑CT扫描正常，但视交叉上核或其输出通路附近的显微镜脑损伤是合理的。
The authors report the case of a 39-year-old sighted woman who displayed non-24-hour sleep-wake cycles following a car accident. The phase relationship between endogenous circadian markers such as plasma melatonin and 6-sulfatoxymelatonin rhythms and self-selected sleep times was abnormal. A laboratory investigation indicated that she was sensitive to bright light as a circadian synchronizer. MRI and brain CT scans were normal, but microscopic brain damage in the vicinity of the suprachiasmatic nucleus or its output pathways is plausible.