Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment.
Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment.
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天然聚合物多酚生物粘合剂凝聚层，具有稳定的湿附着力、抗菌活性和按需分离能力。
DOI：
10.1002/adhm.202304587
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发表时间：
2024
影响因子：
10
通讯作者：
Mano,JoãoF
中科院分区：
文献类型：
--
作者：
Sacramento,MargaridaMA;Oliveira,MarianaB;Gomes,JoséRB;Borges,João;Freedman,BenjaminR;Mooney,DavidJ;Rodrigues,JoãoMM;Mano,JoãoF
医用粘合剂正在成为一种重要的临床工具，作为伤口闭合和愈合以及实现止血中缝线和斯台普斯的辅助剂。然而，临床粘合剂结合细胞相容性，以及在生理条件下的强大和稳定的粘附，仍然是需要的。在此，探索了一种贻贝启发的策略，使用单宁酸（TA）和甲基丙烯酸酯支链淀粉（PUL-MA）生产粘合剂凝聚层。TA| PUL‐MA凝聚层主要包括货车范德华力和疏水相互作用。PUL主链中的甲基丙烯酸基团增加了粘合剂基质中的相互作用数量，与非甲基丙烯酸酯化凝聚层相比，提高了内聚性和粘合强度（72.7 Jm−2）。粘合性能在模拟生理溶液（72.8 Jm−2）中保持72 h。TA的光聚合|PUL‐MA可按需剥离粘合剂。与使用酚基相关的不良细胞相容性在此通过在粘合剂凝聚层中混合活性氧降解酶来规避。这种添加不会影响材料的粘合特性，也不会影响其抗微生物或止血特性。这种经济实惠且简单的方法，加上即使在潮湿环境中也可定制的粘附性，高细胞相容性和抗菌活性，|PUL‐MA作为一种有前途的即用型生物粘合剂用于生物医学应用。
Medical adhesives are emerging as an important clinical tool as adjuvants for sutures and staples in wound closure and healing and in the achievement of hemostasis. However, clinical adhesives combining cytocompatibility, as well as strong and stable adhesion in physiological conditions, are still in demand. Herein, a mussel‐inspired strategy is explored to produce adhesive coacervates using tannic acid (TA) and methacrylate pullulan (PUL‐MA). TA|PUL‐MA coacervates mainly comprise van der Waals forces and hydrophobic interactions. The methacrylic groups in the PUL backbone increase the number of interactions in the adhesives matrix, resulting in enhanced cohesion and adhesion strength (72.7 Jm−2), compared to the non‐methacrylated coacervate. The adhesive properties are kept in physiologic‐mimetic solutions (72.8 Jm−2) for 72 h. The photopolymerization of TA|PUL‐MA enables the on‐demand detachment of the adhesive. The poor cytocompatibility associated with the use of phenolic groups is here circumvented by mixing reactive oxygen species‐degrading enzyme in the adhesive coacervate. This addition does not hamper the adhesive character of the materials, nor their anti‐microbial or hemostatic properties. This affordable and straightforward methodology, together with the tailorable adhesivity even in wet environments, high cytocompatibility, and anti‐bacterial activity, enables foresee TA|PUL‐MA as a promising ready‐to‐use bioadhesive for biomedical applications.