Assessment of ocular irritability of liposome preparations.
Assessment of ocular irritability of liposome preparations.
复制标题
脂质体制剂的眼刺激性评估。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
S. Hayashi
中科院分区：
文献类型：
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作者：
K. Taniguchi;Y. Yamamoto;K. Itakura;H. Miichi;S. Hayashi
用Draize试验、组织学检查和家兔眨眼试验评价中性和正电荷脂质体的眼刺激性。Draize试验的平均总评分（MTS）显示在滴注脂质体制剂后立即略有增加。然而，它没有超过“实际无刺激性水平”，MTS迅速变得低于“无刺激性水平”。在9次滴注各脂质体制剂后，通过光学显微镜未观察到角膜组织学改变。虽然中性脂质体制剂未能增加家兔眨眼次数，但带正电荷的脂质体制剂在很大程度上增加了眨眼次数。证实中性脂质体制剂不会引起眼刺激。然而，带正电荷的脂质体制剂在滴注后可能引起疼痛或不愉快。
Ocular irritability of neutral or positively charged liposomes were assessed by the Draize test, histological examination and the rabbit blinking test. The mean total score (MTS) of the Draize test showed a slight increase immediately following instillation of liposome preparations. However, it did not exceed the "practically nonirritating level", and the MTS rapidly became less than the "nonirritating level". No corneal histological alteration was observed by optical microscopy following 9 instillations of each liposome preparation. Although the neutral liposome preparation failed to increase the rabbit blinking count, the positively charged liposome preparation did so to a significant degree. The neutral liposome preparation was confirmed not to give rise to ocular irritation. However, the positively charged liposome preparation may cause pain or unpleasantness following instillation.