Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.

Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.
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DOI：
10.1126/science.2457254
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发表时间：
1988-08
期刊：
Science
影响因子：
56.9
通讯作者：
M. Wahl;T. Daniel;G. Carpenter
M. Wahl;T. Daniel;G. Carpenter
中科院分区：
综合性期刊1区
文献类型：
--
作者：
M. Wahl;T. Daniel;G. Carpenter

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从用表皮生长因子刺激的A-431表皮样癌细胞提取物中免疫纯化出磷脂酶C活性特异性增加10倍的4，5-二磷酸磷脂酰肌醇（PIP 2）。这一发现表明生长因子刺激的酪氨酸激酶活性和PIP 2水解之间存在生物化学联系。
A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.