The evaluation on neural status of cervical spinal cord in normal and Hirayama disease using diffusion tensor imaging
The evaluation on neural status of cervical spinal cord in normal and Hirayama disease using diffusion tensor imaging
复制标题
弥散张量成像评价正常人和平山病颈脊髓神经状态
DOI：
10.1007/s00586-019-06013-1
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发表时间：
2019-08-01
影响因子：
2.8
通讯作者：
Ma, Xiaosheng
中科院分区：
文献类型：
--
作者：
Sun, Chi;Zhou, Shuyi;Ma, Xiaosheng
目的探讨平山病（Hirayama disease， HD）患者与健康志愿者颈脊髓弥散张量成像（diffusion tensor imaging， DTI）参数的变化，并比较平山病（Hirayama disease， HD）患者颈椎屈曲位与中性位的差异。方法选取17例男性HD患者和11例健康青年男性，分别在颈椎屈曲位和中立位进行DTI扫描。根据在中矢状面绘制的感兴趣区域测量不同水平的FA和ADC值。动态压缩电平的参数分别定义为最低FA和第二最低FA，最高ADC和第二最高ADC。采用患者的臂肩手残疾（DASH）评分对患者进行临床评估。结果HD患者屈曲位FA值较低，ADC值明显高于颈椎中立位。与对照组相比，颈椎中立位HD患者较低水平（c5 /6 ~ C7/T1）的ADC值显著升高，C7/T1的FA值明显降低。HD患者动态压缩水平的FA和ADC值明显偏离对照组较低水平的平均值。动态压缩水平FA和ADC值均与DASH评分相关（FA,R2= 0.520，P= 0.001； ADC,R2= 0.421，P= 0.005）。结论sdti参数支持动态颈椎屈曲压缩假说，无创显示HD患者的神经状态。图形摘要这些幻灯片可以在电子补充材料下检索。
PurposeTo explore the changes in diffusion tensor imaging (DTI) parameters in cervical spinal cord in Hirayama disease (HD) patients and healthy volunteers and to compare these parameters between cervical flexion and neutral positions in HD patients.MethodsSeventeen male patients with HD and eleven healthy young males were included to receive DTI scans in cervical flexion and neutral positions. The FA and ADC values of different levels were measured based on the region of interest drawn on the mid-sagittal plane. The dynamic compressed level’s parameters were defined as the lowest and the second lowest FA and the highest and the second highest ADC, respectively. The clinical assessment of patients was obtained using their disabilities of the arm, shoulder and hand (DASH) scores.ResultsFor the HD patients, the FA values in the cervical flexion position were lower and the ADC values were much higher than those in the cervical neutral position. Compared with the controls, the ADC values were significantly higher in the lower levels (C5/6-C7/T1) and the FA values obviously lower at C7/T1 in HD patients in cervical neutral position. The FA and ADC values of the dynamic compressed level in HD patients deviated significantly from the average of the lower levels in controls. Both the FA and ADC values of the dynamic compressed level correlated with the DASH scores (FA,R2= 0.520,P= 0.001; ADC,R2= 0.421,P= 0.005).ConclusionsDTI parameters can support a hypothesis of dynamic cervical flexion compression and noninvasively reveal the neural status of HD patients.Graphical abstractThese slides can be retrieved under Electronic Supplementary Material.