Young Chinese children without seroprotective hepatitis B surface antibody could be at risk of hepatitis B virus infection through horizontal transmission
Young Chinese children without seroprotective hepatitis B surface antibody could be at risk of hepatitis B virus infection through horizontal transmission
复制标题
没有血清保护性乙型肝炎表面抗体的中国幼儿可能面临通过水平传播感染乙型肝炎病毒的风险
DOI：
10.1111/jvh.13242
复制
发表时间：
2019-12-16
影响因子：
2.5
通讯作者：
Zheng, Xiao-Qun
中科院分区：
文献类型：
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作者：
Pan, Xiao-Ben;Yu, Jian;Zheng, Xiao-Qun
中国历来是慢性乙型肝炎病毒（HBV）感染的高流行地区。母婴传播（MTCT）是乙型肝炎病毒传播的常见途径，可以垂直或水平传播。分娩过程中的垂直传播是乙型肝炎母婴传播的主要途径，多是新生儿在通过产道时接触到含有乙型肝炎病毒的母体体液所致。母婴传播的水平传播不太常见，这种传播是通过接触乙肝病毒携带者母亲出生后的血液或其他体液而发生的。作为预防乙型肝炎传播最经济有效的措施，注射乙型肝炎疫苗和乙型肝炎免疫球蛋白（HBIg）在中国已经实施了二十多年，大大降低了儿童乙型肝炎表面抗原（HBsAg）的患病率。 1 在本研究中，我们旨在调查中国儿童中乙型肝炎病毒传播途径的变化。
China has historically been a highly endemic area for chronic hepatitis B virus (HBV) infection. Mother-to-child transmission (MTCT) represents a frequent route of HBV transmission, which can either occur vertically or horizontally. Vertical transmission during labour is the main route of HBV MTCT, which is mostly caused by exposure of newborn to HBV-containing maternal body fluids when passing through the birth canal. Horizontal transmission of MTCT is less common, which occurs through contact with blood or other bodily fluids of HBV-carrier mothers after birth. As the most cost-effective measures to prevent HBV transmission, injections of HBV vaccine and hepatitis B immunoglobulin (HBIg) have been implemented for over two decades in China, which have led to a great reduction in HBsAg prevalence in the children. 1 In the present study, we aimed to investigate the changes in the HBV transmission route in Chinese children.