Oxidation of urate in human skeletal muscle during exercise
Oxidation of urate in human skeletal muscle during exercise
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DOI：
10.1016/s0891-5849(96)00286-9
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发表时间：
1997-01-01
影响因子：
7.4
通讯作者：
Bangsbo, J
中科院分区：
文献类型：
--
作者：
Hellsten, Y;Tullson, PC;Bangsbo, J
本研究的目的是调查剧烈运动引起的骨骼肌高代谢应激是否会导致运动肌肉中尿酸盐氧化为尿囊素。七名健康男性受试者进行了短期（4.39+/-0.04 [+/-SE] 分钟）力竭自行车运动。肌肉样本取自 m。 v. 锻炼前和锻炼后最初几分钟内的侧肌。在运动前和运动后 45 分钟内采集静脉血样本。肌肉中尿酸盐浓度从静息水平0.26+/-0.023降低至0.084+/-0.016μmol。 g(-1) 重量（p
The purpose of the present study was to investigate whether high metabolic stress to skeletal muscle, induced by intensive exercise, would lead to an oxidation of urate to allantoin in the exercised muscle. Seven healthy male subjects performed short term (4.39+/-0.04 [+/-SE] min) exhaustive cycling exercise. Muscle samples were obtained from m. v. lateralis before and during the first few minutes after the exercise. Venous blood samples were obtained before and up to 45 min after the exercise. The concentration of urate in muscle decreased from a resting level of 0.26+/-0.023 to 0.084+/-0.016 mu mol . g(-1) w.w. (p