Robust microbubble tracking for super resolution imaging in ultrasound
Robust microbubble tracking for super resolution imaging in ultrasound
复制标题
用于超声超分辨率成像的鲁棒微泡跟踪
DOI：
10.1109/ultsym.2016.7728793
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
J. Jensen
中科院分区：
文献类型：
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作者：
Kristoffer B. Hansen;C. A. Villagómez;J. C. Brasen;K. Diamantis;V. Sboros;C. Sørensen;J. Jensen
目前，超声分辨率受衍射的限制，约为所用声波波长的一半。近年来，超分辨率成像技术已经通过定位和跟踪稀疏的微泡组通过脉管系统克服了衍射极限。然而，这仅在固定的组织上进行，限制了其临床应用。本文提出了一种在非固定组织上制作超分辨率图像的技术，该技术首先补偿组织运动，然后跟踪单个微泡。通过输注0.1×原始浓度的SonoVue在麻醉的Sprage-Dawley大鼠的肾脏上进行实验。该算法在体内证明了运动补偿能够消除机械通气引起的运动。结果表明，微气泡定位精度较高，超定位的标准偏差从22μm减小到8 μm。证明了利用微泡进行超分辨成像时，可以消除组织完全固定的限制。
Currently ultrasound resolution is limited by diffraction to approximately half the wavelength of the sound wave employed. In recent years, super resolution imaging techniques have overcome the diffraction limit through the localization and tracking of a sparse set of microbubbles through the vasculature. However, this has only been performed on fixated tissue, limiting its clinical application. This paper proposes a technique for making super resolution images on non-fixated tissue by first compensating for tissue movement and then tracking the individual microbubbles. The experiment is performed on the kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue at 0.1× original concentration. The algorithm demonstrated in vivo that the motion compensation was capable of removing the movement caused by the mechanical ventilator. The results shows that microbubbles were localized with a higher precision, reducing the standard deviation of the super localizations from 22μm to 8 μm. The paper proves that the restriction of completely fixated tissue can be eliminated, when making super resolution imaging with microbubbles.