Neural Modulation of Temporal Encoding, Maintenance, and Decision Processes
Neural Modulation of Temporal Encoding, Maintenance, and Decision Processes
复制标题
DOI：
10.1093/cercor/bhp194
复制
发表时间：
2010-06-01
期刊：
影响因子：
3.7
通讯作者：
Rao, Stephen M.
中科院分区：
文献类型：
--
作者：
Harrington, Deborah L.;Zimbelman, Janice L.;Rao, Stephen M.
时间感知来自通常相互交织的多个过程之间的相互作用。因此，一个挑战是将计时与其他过程分开。虽然纹状体与间隔计时有关，但它也调节非时间过程，如工作记忆。为了区分这些过程，我们分离了与时间感知任务的编码、工作记忆维持和决策阶段相关的神经激活。我们还询问了神经元的持续处理（即，纯音）不同于身份的处理（即，音高感知）或感觉运动特征（即，控制任务）。纹状体激活编码时的持续时间比音高或基本的感觉功能，这并没有差异参与纹状体。在维持阶段，纹状体激活的持续时间和音高相似，但在基线控制任务。在决策阶段，纹状体激活逐步减少，发现在3个任务，激活最大的时间任务和最弱的控制任务。任务相关的纹状体激活在不同的认知阶段，区分的补充运动区，额下回，丘脑，额顶皮层，小脑。我们的研究结果是一致的模型中出现的时间依赖于上下文的皮质纹状体的相互作用。
Time perception emerges from an interaction among multiple processes that are normally intertwined. Therefore, a challenge has been to disentangle timekeeping from other processes. Though the striatum has been implicated in interval timing, it also modulates nontemporal processes such as working memory. To distinguish these processes, we separated neural activation associated with encoding, working-memory maintenance, and decision phases of a time-perception task. We also asked whether neuronal processing of duration (i.e., pure tone) was distinct from the processing of identity (i.e., pitch perception) or sensorimotor features (i.e., control task). Striatal activation was greater when encoding the duration than the pitch or basic sensory features, which did not differentially engage the striatum. During the maintenance phase, striatal activation was similar for duration and pitch but at baseline in the control task. In the decision phase, a stepwise reduction in striatal activation was found across the 3 tasks, with activation greatest in the timing task and weakest in the control task. Task-related striatal activations in different cognitive phases were distinguished from those of the supplementary motor area, inferior frontal gyrus, thalamus, frontoparietal cortices, and the cerebellum. Our results were consistent with a model in which timing emerges from context-dependent corticostriatal interactions.