Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease
Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease
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DOI：
10.1007/s15010-015-0724-7
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发表时间：
2015-06-01
期刊：
影响因子：
7.5
通讯作者：
Nishimura, K.
中科院分区：
文献类型：
--
作者：
Shigemura, T.;Nakazawa, Y.;Nishimura, K.
慢性肉芽肿病(CGD)是一种由细胞内病原体吞噬细胞杀伤功能受损引起的原发免疫缺陷，以反复发生、危及生命的细菌和真菌感染为特征。随着微生物培养和鉴定技术的进步，一些独特的丝状真菌已被报道为CGD患者的重要病原体。我们报告一例慢性萎缩性胃病患者皮下感染家蚕担子菌。据我们所知，这是第一例报告的人类感染这种真菌的病例。根据其形态特征和核糖体RNA基因内转录间隔区的核苷酸序列，对病原菌进行了鉴定。这是第五例丝状担子菌感染CGD患者的病例报告；所有这些病例都是由桑黄属引起的。我们强调了认识到丝状担子菌属种作为CGD患者非曲霉菌真菌感染的可能病原体的重要性。
Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections. As a result of improvements in microbiologic culture and identification techniques, a number of unique filamentous fungi have been reported as significant pathogens in patients with CGD. We report a case of subcutaneous basidiomycete Phellinus mori infection in a patient with CGD. To the best of our knowledge, this is the first reported case of human infection by this fungus. The causative fungus was identified on the basis of its morphological characteristics and nucleotide sequence on the internal transcribed spacer region of the ribosomal RNA gene. This is the fifth case report of filamentous basidiomycetes infecting a patient with CGD; all of these cases have been caused by Phellinus species. We highlight the importance of recognizing filamentous basidiomycetes Phellinus species as possible agents of non-Aspergillus fungal infections in patients with CGD.