DORSAL DIFFERENTIATION OF NEURAL PLATE CELLS INDUCED BY BMP-MEDIATED SIGNALS FROM EPIDERMAL ECTODERM
DORSAL DIFFERENTIATION OF NEURAL PLATE CELLS INDUCED BY BMP-MEDIATED SIGNALS FROM EPIDERMAL ECTODERM
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DOI：
10.1016/0092-8674(95)90276-7
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发表时间：
1995-09-22
期刊：
影响因子：
64.5
通讯作者：
JESSELL, TM
中科院分区：
文献类型：
--
作者：
LIEM, KF;TREMML, G;JESSELL, TM
在神经板外植体中已经检查了控制神经祖细胞的背侧细胞类型的分化的细胞相互作用。在背侧神经管中表达的某些基因最初在神经板内均匀表达，并且似乎通过来自脊索的Sonic hedgehog（SHH）介导的抑制信号来实现其背侧限制。然而，获得确定的背侧细胞命运需要来自表皮外胚层的接触依赖性信号，BMP 4和BMP 7在表皮外胚层中表达，并且这两种蛋白质模仿其诱导活性，BMP 4和相关基因DSL1随后由背侧神经管中的细胞表达。因此，背侧细胞类型的分化似乎是在神经板阶段开始的，并涉及来自表皮外胚层的BMP介导的背侧信号和来自脊索的SHH介导的腹侧信号的对手活动。
The cellular interactions that control the differentiation of dorsal cell types from neural progenitors have been examined in neural plate explants. Certain genes that are expressed in the dorsal neural tube are initially expressed uniformly within the neural plate and appear to achieve their dorsal restriction through a Sonic hedgehog (SHH)-mediated repressive signal from the notochord. The acquisition of definitive dorsal cell fates, however, requires a contact-dependent signal from the epidermal ectoderm, BMP4 and BMP7 are expressed in the epidermal ectoderm, and both proteins mimic its inductive activity, BMP4 and a related gene, DSL1, are subsequently expressed by cells in the dorsal neural tube. The differentiation of dorsal cell types, therefore, appears to be initiated at the neural plate stage and to involve the opponent activities of a BMP-mediated dorsalizing signal from the epidermal ectoderm and a SHH-mediated ventralizing signal from the notochord.